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CCOC(=O)C(C1=CC(=CC(=C1)F)F)(F)FChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | ethyl 2-(3,5-difluorophenyl)-2,2-difluoroacetate |
|---|---|
| IUPAC Name | — |
| CAS Number | 208259-49-8 |
| Database ID | 39058314 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
ethyl 2-(3,5-difluorophenyl)-2,2-difluoroacetate (CAS 208259-49-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 39058314
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-aa05d9852eea4920b9ee880bc0c92408Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of I N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of I N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-8e5c1be30867481cb4076957cdf2e49bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of 1 N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of 1 N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-b3c946918b324de4a196303d0cd3fe8cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of 1 N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of 1 N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-c596f46d38ba49fbb7c2a4e41635c4b8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of 1 N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of 1 N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-d5adb90438f9468b9c57951754cd7984Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of 1 N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of 1 N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-d5adb90438f9468b9c57951754cd7984Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of I N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of I N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-8e5c1be30867481cb4076957cdf2e49bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of I N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of I N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-8e5c1be30867481cb4076957cdf2e49bConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-aa05d9852eea4920b9ee880bc0c92408Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of 1 N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of 1 N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-8375bea36bcc4499ae79ec613f9043a8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of 1 N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of 1 N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-3820d7d88e17444c82efea1520cb64d2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl 3,5-difluorophenyl-α,α-difluoroacetate (from Example D24 below; 1 molar eq.) in 50% aqueous ethanol was treated with lithium hydroxide (1.5 molar eq.). The solution was stirred for 3 hours at ambient temperature then concentrated via rotary evaporation. The residue was taken up in water; a small amount of 1 N NaOH was added to make basic. The aqueous mixture was extracted with ether. The aqueous layer was acidified to pH 3 with 1 N HCl. The acid was extracted thrice with methylene chloride. The combined methylene chloride extracts were dried over Na2SO4, filtered, and concentrated. then concentrated via rotary evaporation a small amount of 1 N NaOH was added The aqueous mixture was extracted with ether The acid was extracted thrice with methylene chloride The combined methylene chloride extracts were dried over Na2SO4 filtered concentrated
Source ID: ord-b3c946918b324de4a196303d0cd3fe8cPubChem References
These sources are listed in the compound's public database record.
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