4-[(2,6-difluorophenyl)methyl]piperidine;hydrochloride

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared from 2-(4-benzyloxyphenoxy)ethyl bromide (0.393 g, 1.28 mmol), 4-(2,6-difluorobenzyl)piperidine hydrochloride (0.317 g, 1.28 mmol) and potassium carbonate (0.444 g, 3.2 mmol) in two steps as off white solid (0.240 g). mp 198-200° C. 1H NMR (CD3OD) 1.595 (m, 2 H), 1.906 (m, 3 H), 2.705 (d, J=5.7 Hz, 2 H), 3.029 (t, J=12.3 Hz, 2 H), 3.303 (m, 2 H), 3.629 (d, J=12.6 Hz, 2 H), 4.238 (t, J=4.5 Hz, 2 H), 6.702 (d, J=9.0 Hz, 2 H), 6.825 (d, J=9.0 Hz, 2 H), 6.953 (m, 2 H), 7.277 (m, 1 H).