No renderable structure data available
CC(=O)CCC1CCCC1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 4-cyclopentylbutan-2-one |
|---|---|
| IUPAC Name | — |
| CAS Number | 18216-75-6 |
| Database ID | 12427701 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
4-cyclopentylbutan-2-one (CAS 18216-75-6) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 12427701
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
8 reactions · 8 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d5fde7a9ba1948c7a4e60214eb06de03Conditions: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 parts of 3-cyclopentyl propionic acid are dissolved in 150 parts by volume of ethyl ether and chilled to -20° C. under argon. 50 parts by volume of 2.8 molar methyl magnesium bromide are added dropwise. After the addition of the methyl magnesium bromide is completed, the mixture is allowed to warm to room temperature. The cloudy reaction mixture is treated with 1N hydrochloric acid and the clearified reaction mixture is extracted with ether followed by ethyl acetate. The combined organic extracts are washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure. The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent, to provide 4-cyclopentyl-2-butanone. to warm to room temperature The cloudy reaction mixture the clearified reaction mixture is extracted with ether The combined organic extracts are washed with water and saturated sodium chloride solution dried over anhydrous sodium sulfate filtered the solvent evaporated under reduced pressure The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent
Source ID: ord-477d46f4e8b242e8b6ba3cdcf2761c43Conditions: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 parts of 3-cyclopentyl propionic acid are dissolved in 150 parts by volume of ethyl ether and chilled to -20° C. under argon. 50 parts by volume of 2.8 molar methyl magnesium bromide are added dropwise. After the addition of the methyl magnesium bromide is completed, the mixture is allowed to warm to room temperature. The cloudy reaction mixture is treated with 1N hydrochloric acid and the clearified reaction mixture is extracted with ether followed by ethyl acetate. The combined organic extracts are washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure. The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent, to provide 4-cyclopentyl-2-butanone. to warm to room temperature The cloudy reaction mixture the clearified reaction mixture is extracted with ether The combined organic extracts are washed with water and saturated sodium chloride solution dried over anhydrous sodium sulfate filtered the solvent evaporated under reduced pressure The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent
Source ID: ord-6f79f686753c4eceb89340a9860a170dConditions: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 Parts of 3-cyclopentyl propionic acid are dissolved in 150 parts by volume of ethyl ether and chilled to -20° C. under argon. 50 Parts by volume of 2.8 molar methyl magnesium bromide are added dropwise. After the addition of the methyl magnesium bromide is completed, the mixture is allowed to warm to room temperature. The cloudy reaction mixture is treated with 1N hydrochloric acid and the clearified reaction mixture is extracted with ether followed by ethyl acetate. The combined organic extracts are washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure. The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent, to provide 4-cyclopentyl-2-butanone. to warm to room temperature The cloudy reaction mixture the clearified reaction mixture is extracted with ether The combined organic extracts are washed with water and saturated sodium chloride solution dried over anhydrous sodium sulfate filtered the solvent evaporated under reduced pressure The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent
Source ID: ord-059cd2243de54bd6b696ae6fdc329178Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d5fde7a9ba1948c7a4e60214eb06de03Conditions: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 parts of 3-cyclopentyl propionic acid are dissolved in 150 parts by volume of ethyl ether and chilled to -20° C. under argon. 50 parts by volume of 2.8 molar methyl magnesium bromide are added dropwise. After the addition of the methyl magnesium bromide is completed, the mixture is allowed to warm to room temperature. The cloudy reaction mixture is treated with 1N hydrochloric acid and the clearified reaction mixture is extracted with ether followed by ethyl acetate. The combined organic extracts are washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure. The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent, to provide 4-cyclopentyl-2-butanone. to warm to room temperature The cloudy reaction mixture the clearified reaction mixture is extracted with ether The combined organic extracts are washed with water and saturated sodium chloride solution dried over anhydrous sodium sulfate filtered the solvent evaporated under reduced pressure The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent
Source ID: ord-477d46f4e8b242e8b6ba3cdcf2761c43Conditions: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 parts of 3-cyclopentyl propionic acid are dissolved in 150 parts by volume of ethyl ether and chilled to -20° C. under argon. 50 parts by volume of 2.8 molar methyl magnesium bromide are added dropwise. After the addition of the methyl magnesium bromide is completed, the mixture is allowed to warm to room temperature. The cloudy reaction mixture is treated with 1N hydrochloric acid and the clearified reaction mixture is extracted with ether followed by ethyl acetate. The combined organic extracts are washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure. The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent, to provide 4-cyclopentyl-2-butanone. to warm to room temperature The cloudy reaction mixture the clearified reaction mixture is extracted with ether The combined organic extracts are washed with water and saturated sodium chloride solution dried over anhydrous sodium sulfate filtered the solvent evaporated under reduced pressure The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent
Source ID: ord-6f79f686753c4eceb89340a9860a170dConditions: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 Parts of 3-cyclopentyl propionic acid are dissolved in 150 parts by volume of ethyl ether and chilled to -20° C. under argon. 50 Parts by volume of 2.8 molar methyl magnesium bromide are added dropwise. After the addition of the methyl magnesium bromide is completed, the mixture is allowed to warm to room temperature. The cloudy reaction mixture is treated with 1N hydrochloric acid and the clearified reaction mixture is extracted with ether followed by ethyl acetate. The combined organic extracts are washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure. The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent, to provide 4-cyclopentyl-2-butanone. to warm to room temperature The cloudy reaction mixture the clearified reaction mixture is extracted with ether The combined organic extracts are washed with water and saturated sodium chloride solution dried over anhydrous sodium sulfate filtered the solvent evaporated under reduced pressure The residual oil is chromatographed on silica gel using 10% ethyl acetate/hexane as the eluent
Source ID: ord-059cd2243de54bd6b696ae6fdc329178PubChem References
These sources are listed in the compound's public database record.
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