No renderable structure data available
CCOP(=O)(C1=CC=CC=C1)OCCChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | diethoxyphosphorylbenzene |
|---|---|
| IUPAC Name | — |
| CAS Number | 1754-49-0 |
| Database ID | 15642 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
diethoxyphosphorylbenzene (CAS 1754-49-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 15642
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
11 reactions · 11 references
Conditions: temp:40.01; pressure:0.00; stir:
Source ID: ord-bb26d8cdc9bf4a2e841834c2b3596c72Conditions: temp:40.01; pressure:0.00; stir:
Source ID: ord-32d52966647c464e901c99dd1fade510Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II)acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-57dc295fc12646f5bca20cc7ccbef0ecConditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II)acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-57dc295fc12646f5bca20cc7ccbef0ecConditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II) acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-2357e0da1d7a4fd9abeb5769e85d37d1Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II) acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-2357e0da1d7a4fd9abeb5769e85d37d1Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II) acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-41b32a6a2cd047a5a12108a332b6556dConditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II) acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents), and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-e25e0eaaa5204dc6843cfac9b176aa93Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II) acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro [4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μl, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μl, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80 ° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125 -mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-6d7e3db2eeb94157b374258d19ca9202Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II)acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-57dc295fc12646f5bca20cc7ccbef0ecConditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar was charged with palladium(II) acetate (1.4 mg, 0.00637 mmol, 0.02 equivalents), 8-(1,1′-binaphthyl-2-yl)-7,7,9,9-tetramethyl-1,4-dioxa-8-phosphaspiro[4.5]decane (3.6 mg, 0.00764 mmol, 0.024 equivalents) and ethanol (0.64 mL). To the slurry were added triethylamine (67 μL, 0.478 mmol, 1.5 equivalents), bromobenzene (34 μL, 0.318 mmol, 1 equivalent) and diethylphosphite (49 μL, 0.382 mmol, 1.2 equivalents). The vial was sealed with a crimp top and stirred at 80° C. After 24 hours, the vial was removed from the heating block, cooled to room temperature and brought out of the glovebox. The reaction solution was diluted with tetrahydrofuran (2 mL) and filtered into a tared 125-mL Erlenmeyer flask. The vial was rinsed with tetrahydrofuran (5×1 mL), followed by washing of the filter cake with tetrahydrofuran (5 mL). A wt % analysis was performed on the filtrate and an assay yield of 59% was measured versus commercially available diethyl phenylphosphonate. In a nitrogen-atmosphere glovebox, a microwave vial equipped with a magnetic stir bar The vial was sealed with a crimp top the vial was removed from the heating block cooled to room temperature The reaction solution was diluted with tetrahydrofuran (2 mL) filtered into a tared 125-mL Erlenmeyer flask The vial was rinsed with tetrahydrofuran (5×1 mL) by washing of the filter cake with tetrahydrofuran (5 mL)
Source ID: ord-2357e0da1d7a4fd9abeb5769e85d37d1PubChem References
These sources are listed in the compound's public database record.
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