No renderable structure data available
C1CCN(C1)S(=O)(=O)C2=CC=C(C=C2)IChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1-(4-iodophenyl)sulfonylpyrrolidine |
|---|---|
| IUPAC Name | — |
| CAS Number | 167156-16-3 |
| Database ID | 874532 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1-(4-iodophenyl)sulfonylpyrrolidine (CAS 167156-16-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 874532
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-aa889bceea0d47449cb401156486bfa2Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-aa889bceea0d47449cb401156486bfa2Conditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Copper (1) chloride (0.038 g) was added to a mixture of (R)-N-(2-chloro-4-mercaptophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (Example 210) (0.21 g), N-(4-iodobenzenesulphonyl)pyrrolidine (0.258 g) and sodium methoxide (0.042 g) in DMA (5 ml). The mixture was heated at 150° C. with stirring for 4 hours then cooled and the DMA removed by evaporation. Ethyl acetate (20 ml) and water (20 ml) was added and the mixture was filtered. The aqueous layer was extracted with ethyl acetate (3×20 ml) and the organic layers were combined and dried. Volatile material was removed by evaporation and the residue was purified on a silica gel Mega Bond Elut column, eluting with methanol/DCM 0-10% to give the title compound (0.16 g) as a solid. NMR (CDCl3): 1.75 (s, 3H), 1.75-1.85 (m, 4H), 3.2-3.3 (m, 4H), 4.0 (s, 1H), 7.2-7.3 (m, 2H), 7.4-7.45 (m, 1H), 7.6 (s, 1), 7.7 (d, 2H), 8.45 (d, 1H), 9.15 (s, 1H); MS (ESP−): 507. then cooled the DMA removed by evaporation Ethyl acetate (20 ml) and water (20 ml) was added the mixture was filtered The aqueous layer was extracted with ethyl acetate (3×20 ml) dried Volatile material was removed by evaporation the residue was purified on a silica gel Mega Bond Elut column eluting with methanol/DCM 0-10%
Source ID: ord-acd0253acaae4a3d8aaba5c09bd405f7Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared from 1-[(4-iodophenyl)sulfonyl]pyrrolidine and 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole using a similar procedure to that described for Example 87.
Source ID: ord-745200c58eda47c78a7eed3fac0a2f6aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared from 4-iodobenzenesulfonyl chloride and pyrrolidine using a similar procedure to that described for Description 30.
Source ID: ord-e271cad3ffe545008bd2896cace61e62Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared from 1-[(4-iodophenyl)sulfonyl]pyrrolidine and 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole using a similar procedure to that described for Example 87.
Source ID: ord-745200c58eda47c78a7eed3fac0a2f6aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared from 4-iodobenzenesulfonyl chloride and pyrrolidine using a similar procedure to that described for Description 30.
Source ID: ord-e271cad3ffe545008bd2896cace61e62Conditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Copper(I) chloride (0.038 g) was added to a mixture of (R)-N-(2-chloro-4-mercaptophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (Example 210) (0.21 g), N-(4-iodobenzenesulphonyl)pyrrolidine (0.258 g) and sodium methoxide (0.042 g) in DMA (5 ml). The mixture was heated at 150° C. with stirring for 4 hours then cooled and the DMA removed by evaporation. Ethyl acetate (20 ml) and water (20 ml) was added and the mixture was filtered. The aqueous layer was extracted with ethyl acetate (3×20 ml) and the organic layers were combined and dried. Volatile material was removed by evaporation and the residue was purified on a silica gel Mega Bond Elut column, eluting with methanol/DCM 0-10% to give the title compound (0.16 g) as a solid. NMR (CDCl3): 1.75 (s, 3H), 1.75-1.85 (m, 4H), 3.2-3.3 (m, 4H), 4.0 (s, 1H), 7.2-7.3 (m, 2H), 7.4-7.45 (m, 1H), 7.6 (s, 1H), 7.7 (d, 2H), 8.45 (d, 1H), 9.15 (s, 1H); MS (ESP−): 507. then cooled the DMA removed by evaporation Ethyl acetate (20 ml) and water (20 ml) was added the mixture was filtered The aqueous layer was extracted with ethyl acetate (3×20 ml) dried Volatile material was removed by evaporation the residue was purified on a silica gel Mega Bond Elut column eluting with methanol/DCM 0-10%
Source ID: ord-fba4f5f183ef4e1b9b12e0ddcc0150d2Conditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Copper(I) chloride (0.038 g) was added to a mixture of (R)-N-(2-chloro-4-mercaptophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (Example 210) (0.21 g), N-(4-iodobenzenesulphonyl)pyrrolidine (0.258 g) and sodium methoxide (0.042 g) in DMA (5 ml). The mixture was heated at 150° C. with stirring for 4 hours then cooled and the DMA removed by evaporation. Ethyl acetate (20 ml) and water (20 ml) was added and the mixture was filtered. The aqueous layer was extracted with ethyl acetate (3×20 ml) and the organic layers were combined and dried. Volatile material was removed by evaporation and the residue was purified on a silica gel Mega Bond Elut column, eluting with methanol/DCM 0-10% to give the title compound (0.16 g) as a solid. NMR (CDCl3): 1.75 (s, 3H), 1.75-1.85 (m, 4H), 3.2-3.3 (m, 4H), 4.0 (s, 1H), 7.2-7.3 (m, 2H), 7.4-7.45 (m, 1H), 7.6 (s, 1H), 7.7 (d, 2H), 8.45 (d, 1H), 9.15 (s, 1H); MS (ESP−): 507. then cooled the DMA removed by evaporation Ethyl acetate (20 ml) and water (20 ml) was added the mixture was filtered The aqueous layer was extracted with ethyl acetate (3×20 ml) dried Volatile material was removed by evaporation the residue was purified on a silica gel Mega Bond Elut column eluting with methanol/DCM 0-10%
Source ID: ord-fba4f5f183ef4e1b9b12e0ddcc0150d2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared from 1-[(4-iodophenyl)sulfonyl]pyrrolidine and 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole using a similar procedure to that described for Example 87.
Source ID: ord-889c511e9bd3489bbd006a13d1de9576Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared from 4-iodobenzenesulfonyl chloride and pyrrolidine using a similar procedure to that described for Description 30.
Source ID: ord-96db3eae5b874d4389a51ca829db924fConditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Copper (1) chloride (0.038 g) was added to a mixture of (R)-N-(2-chloro-4-mercaptophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (Example 210) (0.21 g), N-(4-iodobenzenesulphonyl)pyrrolidine (0.258 g) and sodium methoxide (0.042 g) in DMA (5 ml). The mixture was heated at 150° C. with stirring for 4 hours then cooled and the DMA removed by evaporation. Ethyl acetate (20 ml) and water (20 ml) was added and the mixture was filtered. The aqueous layer was extracted with ethyl acetate (3×20 ml) and the organic layers were combined and dried. Volatile material was removed by evaporation and the residue was purified on a silica gel Mega Bond Elut column, eluting with methanol/DCM 0-10% to give the title compound (0.16 g) as a solid. NMR (CDCl3): 1.75 (s, 3H), 1.75-1.85 (m, 4H), 3.2-3.3 (m, 4H), 4.0 (s, 1H), 7.2-7.3 (m, 2H), 7.4-7.45 (m, 1H), 7.6 (s, 1), 7.7 (d, 2H), 8.45 (d, 1H), 9.15 (s, 1H); MS (ESP−): 507. then cooled the DMA removed by evaporation Ethyl acetate (20 ml) and water (20 ml) was added the mixture was filtered The aqueous layer was extracted with ethyl acetate (3×20 ml) dried Volatile material was removed by evaporation the residue was purified on a silica gel Mega Bond Elut column eluting with methanol/DCM 0-10%
Source ID: ord-acd0253acaae4a3d8aaba5c09bd405f7PubChem References
These sources are listed in the compound's public database record.
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