3-[(4-methylphenyl)methylamino]propan-1-ol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 4-chloro-3-methylsulfanyl-6-methyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine (788 mg, 2 mmol) and 3-(p-methylbenzyl)amino-1-propanol (716 mg, 4 mmol) in 10 ml of acetonitrile was heated at reflux for 4 hours. The mixture was cooled, quenched with water and dilute hydrogen chloride and extracted with ethyl acetate. The organic layer was washed with aqueous sodium bicarbonate and brine, separated, dried and concentrated to give 953 mg of the title compound as an off-white glass form. The material was purified through silica gel column chromatography using chloroform as eluent to give the title compound as a white glass form. 1H NMR (CDCl3): 1.79 (m, 2H), 2.38 (s, 3H), 2.52 (s, 3H), 2.54 (s, 3H), 3.56 (t, 2H), 3.86 (t, 2H), 5.12 (s, 2H), 7.20 (s, 4H), 7.51 (s,2H) ppm. 13C NMR (CDCl3): 16.20, 21.13, 25.53, 29.64, 43.51, 53.88, 58.24, 127.78, 128.77, 129.33, 133.51, 136.18, 137.41, 142.93, 159.13, 164.89 ppm. IR(KBr): 3350, 2935, 1540 cm−1. Anal. calc. for C24H24N5OSCl3: C, 53.69; H, 4.50; N, 13.04; found: C, 53.33, H, 4.44, N, 12.84. was heated at reflux for 4 hours The mixture was cooled quenched with water and dilute hydrogen chloride extracted with ethyl acetate The organic layer was washed with aqueous sodium bicarbonate and brine separated dried concentrated

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 4-chloro-3-methylsulfanyl-6-methyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine (788 mg, 2 mmol) and 3-(p-methylbenzyl)amino-1-propanol (716 mg, 4 mmol) in 10 ml of acetonitrile was heated at reflux for 4 hours. The mixture was cooled, quenched with water and dilute hydrogen chloride and extracted with ethyl acetate. The organic layer was washed with aqueous sodium bicarbonate and brine, separated, dried and concentrated to give 953 mg of the title compound as an off-white glass form. The material was purified through silica gel column chromatography using chloroform as eluent to give the title compound as a white glass form. 1H NMR (CDCl3): 1.79 (m, 2H), 2.38 (s, 3H), 2.52 (s, 3H), 2.54 (s, 3H), 3.56 (t, 2H), 3.86 (t, 2H), 5.12 (s, 2H), 7.20 (s, 4H), 7.51 (s,2H) ppm. 13C NMR (CDCl3): 16.20, 21.13, 25.53, 29.64, 43.51, 53.88, 58.24, 127.78, 128.77, 129.33, 133.51, 136.18, 137.41, 142.93, 159.13, 164.89 ppm. IR(KBr): 3350, 2935, 1540 cm−1. Anal. calc. for C24H24N5OSCl3: C, 53.69; H, 4.50; N, 13.04; found: C, 53.33, H, 4.44, N, 12.84. was heated at reflux for 4 hours The mixture was cooled quenched with water and dilute hydrogen chloride extracted with ethyl acetate The organic layer was washed with aqueous sodium bicarbonate and brine separated dried concentrated

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 4-chloro-3-methylsulfanyl-6-methyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine (788 mg, 2 mmol) and 3-(p-methylbenzyl)amino-1-propanol (716 mg, 4 mmol) in 10 ml of acetonitrile was heated at reflux for 4 hours. The mixture was cooled, quenched with water and dilute hydrogen chloride and extracted with ethyl acetate. The organic layer was washed with aqueous sodium bicarbonate and brine, separated, dried and concentrated to give 953 mg of the title compound as an off-white glass form. The material was purified through silica gel column chromatography using chloroform as eluent to give the title compound as a white glass form. 1H NMR (CDCl3): 1.79 (m, 2H), 2.38 (s, 3H), 2.52 (s, 3H), 2.54 (s, 3H), 3.56 (t, 2H), 3.86 (t, 2H), 5.12 (s, 2H), 7.20 (s, 4H), 7.51 (s,2H) ppm. 13C NMR (CDCl3): 16.20, 21.13, 25.53, 29.64, 43.51, 53.88, 58.24, 127.78, 128.77, 129.33, 133.51, 136.18, 137.41, 142.93, 159.13, 164.89 ppm. IR(KBr): 3350, 2935, 1540 cm−1. Anal. calc. for C24H24N5OSCl3: C, 53.69; H, 4.50; N, 13.04; found: C, 53.33, H, 4.44, N, 12.84. was heated at reflux for 4 hours The mixture was cooled quenched with water and dilute hydrogen chloride extracted with ethyl acetate The organic layer was washed with aqueous sodium bicarbonate and brine separated dried concentrated

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 4-chloro-3-methylsulfanyl-6-methyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine (788 mg, 2 mmol) and 3-(p-methylbenzyl)amino-1-propanol (716 mg, 4 mmol) in 10 ml of acetonitrile was heated at reflux for 4 hours. The mixture was cooled, quenched with water and dilute hydrogen chloride and extracted with ethyl acetate. The organic layer was washed with aqueous sodium bicarbonate and brine, separated, dried and concentrated to give 953 mg of the title compound as an off-white glass form. The material was purified through silica gel column chromatography using chloroform as eluent to give the title compound as a white glass form. 1H NMR (CDCl3): 1.79 (m, 2H), 2.38 (s, 3H), 2.52 (s, 3H), 2.54 (s, 3H), 3.56 (t, 2H), 3.86 (t, 2H), 5.12 (s, 2H), 7.20 (s, 4H), 7.51 (s,2H) ppm. 13C NMR (CDCl3): 16.20, 21.13, 25.53, 29.64, 43.51, 53.88, 58.24, 127.78, 128.77, 129.33, 133.51, 136.18, 137.41, 142.93, 159.13, 164.89 ppm. IR(KBr): 3350, 2935, 1540 cm−1. Anal. calc. for C24H24N5OSCl3: C, 53.69; H, 4.50; N, 13.04; found: C, 53.33, H, 4.44, N, 12.84. was heated at reflux for 4 hours The mixture was cooled quenched with water and dilute hydrogen chloride extracted with ethyl acetate The organic layer was washed with aqueous sodium bicarbonate and brine separated dried concentrated