Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 3-methoxypropan-1-ol [Fluka product #38457] (3.1 mL, 32 mmol) and triphenylphosphine (8.4 g, 32 mmol) in tetrahydrofuran (93 mL) at 0° C. was treated with diisopropyl azodicarboxylate (6.7 mL, 34 mmol) dropwise. The reaction mixture was stirred at 0° C. for 15 min, treated with a solution of N-{4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}-2,2,2-trifluoroacetamide (10 g, 23 mmol) in tetrahydrofuran (47 mL), and stirred at 25° C. for 72 h. The reaction mixture was concentrated, diluted with ethyl acetate (200 mL), treated with trifluoroacetic acid (20 mL) and water (20 mL), and heated at 50° C. for 6 h. The reaction mixture was concentrated, rediluted with ethyl acetate (200 mL) and washed with water (3×80 mL), saturated sodium bicarbonate (2×80 mL) and brine (80 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to a crude residue. This material was purified on silica gel to give the desired product (6.4 g, 54%) as a white solid. LCMS for C14H14BrFN5O4 (M+H)+: m/z=414.0, 416.0.
stirred at 25° C. for 72 h
The reaction mixture was concentrated
diluted with ethyl acetate (200 mL)
treated with trifluoroacetic acid (20 mL) and water (20 mL)
heated at 50° C. for 6 h
The reaction mixture was concentrated
rediluted with ethyl acetate (200 mL)
washed with water (3×80 mL), saturated sodium bicarbonate (2×80 mL) and brine (80 mL)
dried over anhydrous sodium sulfate
filtered
concentrated to a crude residue
This material was purified on silica gel
Source ID: ord-d424ea94f0254c7c83223bbfbd754a39