1-cyclohexylbutan-1-one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 130 parts of 1-cyclohexyl-1-butanone, 225 parts of methyl glycine, 2 parts of a solution of thiophene in methanol 4%, 960 parts of methanol and 200 parts of potassium acetate was hydrogenated overnight in a Parr apparatus with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was taken up in water and 1,1'-oxybisethane. The whole was extracted with a hydrochloric acid solution 10%. The aqueous layer was treated with a sodium hydroxide solution and the product was extracted with 1,1'-oxybisethane. The extract was dried, filtered and evaporated, yielding 46 parts (22.4%) of methyl N-(1-cyclohexylbutyl)glycine as a residue (int. 3). the catalyst was filtered off the filtrate was evaporated The whole was extracted with a hydrochloric acid solution 10% The aqueous layer was treated with a sodium hydroxide solution the product was extracted with 1,1'-oxybisethane The extract was dried filtered evaporated