methyl (2S)-2,3-dihydro-1H-indole-2-carboxylate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Working in a manner similar to preparation IL, starting with the 4-(phenylmethoxy)benzenesulfonyl chloride and 2,3-dihydro-(2S)-1H-indole-2-carboxylic acid methyl ester, the expected product is obtained in the form of a white powder with a yield of 81%. Working in a manner similar to preparation IL

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Working in a manner similar to preparation IL, starting with the 4-(phenylmethoxy)benzenesulfonyl chloride and 2,3-dihydro-(2S)-1H-indole-2-carboxylic acid methyl ester, the expected product is obtained in the form of a white powder with a yield of 81%. Working in a manner similar to preparation IL

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Working in a manner similar to preparation IL, starting with the 4-(phenylmethoxy)benzenesulfonyl chloride and 2,3-dihydro-(2S)-1H-indole-2-carboxylic acid methyl ester, the expected product is obtained in the form of a white powder with a yield of 81%. Working in a manner similar to preparation IL

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Indoline-2(S)-carboxylic acid (10 g, 64 mmol) was refluxed in a mixture of methanol (50 ml) and sulphuric acid (8 ml) for 5 h. The solvent was removed to give the product in the form of an oil. The solvent was removed to give the product in the form of an oil

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: There are introduced into a reactor, with stirring, 2.13 kg of methyl(2S)-2,3-dihydroindole-2-carboxylate, 1 kg of triethylamine, 30 litres of tetrahydrofuran and then, after 10 minutes' stirring at room temperature, 1.9 kg of N-[tert-butyloxycarbonyl]-(S)-alanine and 2 kg of dicyclohexylcarbodiimide. The heterogeneous mixture is then stirred at room temperature for 6 hours, and is subsequently cooled to 0° C. and filtered. There are introduced into a reactor The heterogeneous mixture is then stirred at room temperature for 6 hours filtered

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Working in a manner similar to preparation IL, starting with the 4-(phenylmethoxy)benzenesulfonyl chloride and 2,3-dihydro-(2S)-1H-indole-2-carboxylic acid methyl ester, the expected product is obtained in the form of a white powder with a yield of 81%. Working in a manner similar to preparation IL