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CC1(CCC(=O)NC1=O)CChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 3,3-dimethylpiperidine-2,6-dione |
|---|---|
| IUPAC Name | — |
| CAS Number | 1194-33-8 |
| Database ID | 121048 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
3,3-dimethylpiperidine-2,6-dione (CAS 1194-33-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 121048
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-114fe39f071f433cb459f230d5c70d1aConditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-8ed025b555e14d3796f947388c315afaConditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-3c46b5a6c0dc4f8fbcbdb201366827e0Conditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-839758e16358461ea01e3ad93e9d6318Conditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-839758e16358461ea01e3ad93e9d6318Conditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-087f03901a774dafb10b459132bce187Conditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-45e5628d81f34262862147f0926895a4Conditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-8ed025b555e14d3796f947388c315afaConditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-3c46b5a6c0dc4f8fbcbdb201366827e0Conditions: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione. the mixture was cooled to near room temperature The mixture was extracted with ethyl acetate three times The organic layers were washed with a saturated sodium chloride aqueous solution dried over anhydrous magnesium sulfate concentrated
Source ID: ord-839758e16358461ea01e3ad93e9d6318PubChem References
These sources are listed in the compound's public database record.
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