N-pentan-3-ylidenehydroxylamine

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of pentan-3-one oxime (6.00 g) in dimethylformamide (30 ml) was added sodium hydride (60% oil suspension, 2.37 g) under ice cooling. After 15 minutes, to the above mixture was added dropwise 1-fluoro-2-nitrobenzene (5.98 g) in dimethylformamide (30 ml). The mixture was stirred for 3 hours at ambient temperature and poured into a mixture of ice and water. The separated oil was extracted with diethyl ether. The organic layer was washed with water, dried over sodium sulfate and evaporated in vacuo to give pentan-3-one O-(2-nitrophenyl)oxime (10.51 g) as a brown oil. The separated oil was extracted with diethyl ether The organic layer was washed with water dried over sodium sulfate evaporated in vacuo

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.0 g of 3 hydroxypicolinic acid, 10 ml of N,N-dimethylformamide was added, and then 5.9 g of thionyl chloride was dropwise added thereto at a temperature of at most 10° C. The mixture was stirred at 0° C. for 30 minutes. To the reaction solution, 30 ml of chloroform was added, and the mixture was further stirred at 0° C. for 15 minutes. Then, a solution prepared by dissolving 5.0 g of diethyl ketone oxime in 50 ml of chloroform was dropwise added thereto at 0° C., and the mixture was stirred for 30 minutes. Then, 7.9 g of pyridine was dropwise added thereto. Then, the reaction solution was stirred at 0° C. for one hour and at room temperature for one day. The reaction solution was poured into water and extracted with ethyl acetate. Then, the extract was washed with a saturated sodium hydrogencarbonate aqueous solution and with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue thereby obtained was purified by silica gel column chromatography by using as a developing solvent a mixture of hexane/ethyl ether to obtain 6.5 g of the above identified compound as slightly yellow transparent viscous liquid. at a temperature of at most 10° C the mixture was further stirred at 0° C. for 15 minutes Then, a solution prepared was dropwise added at 0° C., and the mixture was stirred for 30 minutes Then, the reaction solution was stirred at 0° C. for one hour and at room temperature for one day extracted with ethyl acetate Then, the extract was washed with a saturated sodium hydrogencarbonate aqueous solution and with a saturated sodium chloride aqueous solution dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure the residue thereby obtained was purified by silica gel column chromatography a mixture of hexane/ethyl ether to obtain 6.5 g of the

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of pentan-3-one oxime (6.00 g) in dimethylformamide (30 ml) was added sodium hydride (60% oil suspension, 2.37 g) under ice cooling. After 15 minutes, to the above mixture was added dropwise 1-fluoro-2-nitrobenzene (5.98 g) in dimethylformamide (30 ml). The mixture was stirred for 3 hours at ambient temperature and poured into a mixture of ice and water. The separated oil was extracted with diethyl ether. The organic layer was washed with water, dried over sodium sulfate and evaporated in vacuo to give pentan-3-one O-(2-nitrophenyl)oxime (10.51 g) as a brown oil. The separated oil was extracted with diethyl ether The organic layer was washed with water dried over sodium sulfate evaporated in vacuo

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of pentan-3-one oxime (6.00 g) in dimethylformamide (30 ml) was added sodium hydride (60% oil suspension, 2.37 g) under ice cooling. After 15 minutes, to the above mixture was added dropwise 1-fluoro-2-nitrobenzene (5.98 g) in dimethylformamide (30 ml). The mixture was stirred for 3 hours at ambient temperature and poured into a mixture of ice and water. The separated oil was extracted with diethyl ether. The organic layer was washed with water, dried over sodium sulfate and evaporated in vacuo to give pentan-3-one O-(2-nitrophenyl)oxime (10.51 g) as a brown oil. The separated oil was extracted with diethyl ether The organic layer was washed with water dried over sodium sulfate evaporated in vacuo

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 0.9 g of 3-pentanone oxime is added at room temperature to a suspension of 3.0 g of 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzoic acid in 50 ml of diethyl ether. Thereafter, a solution of 1.9 g of dicyclohexylcarbodiimide and 0.1 g of 4-pyrrolidinopyridine in 15 ml of diethyl ether is added dropwise over 10 minutes. The reaction mixture is stirred at room temperature for 12 hours. Subsequently, it is filtered and evaporated to dryness under reduced pressure. The residue is purified by chromatography on silica gel with n-hexane/diethyl ether (4:1) as the eluent. In this manner there is obtained 3-pentanone O-{2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4 -trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzoyl}oxime, m.p. 128°-130° C. Subsequently, it is filtered evaporated to dryness under reduced pressure The residue is purified by chromatography on silica gel with n-hexane/diethyl ether (4:1) as the eluent

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 0.9 g of 3-pentanone oxime is added at room temperature to a suspension of 3.0 g of 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzoic acid in 50 ml of diethyl ether. Thereafter, a solution of 1.9 g of dicyclohexylcarbodiimide and 0.1 g of 4-pyrrolidinopyridine in 15 ml of diethyl ether is added dropwise over 10 minutes. The reaction mixture is stirred at room temperature for 12 hours. Subsequently, it is filtered and evaporated to dryness under reduced pressure. The residue is purified by chromatography on silica gel with n-hexane/diethyl ether (4:1) as the eluent. In this manner there is obtained 3-pentanone O-{2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4 -trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzoyl}oxime, m.p. 128°-130° C. Subsequently, it is filtered evaporated to dryness under reduced pressure The residue is purified by chromatography on silica gel with n-hexane/diethyl ether (4:1) as the eluent

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 0.9 g of 3-pentanone oxime is added at room temperature to a suspension of 3.0 g of 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzoic acid in 50 ml of diethyl ether. Thereafter, a solution of 1.9 g of dicyclohexylcarbodiimide and 0.1 g of 4-pyrrolidinopyridine in 15 ml of diethyl ether is added dropwise over 10 minutes. The reaction mixture is stirred at room temperature for 12 hours. Subsequently, it is filtered and evaporated to dryness under reduced pressure. The residue is purified by chromatography on silica gel with n-hexane/diethyl ether (4:1) as the eluent. In this manner there is obtained 3-pentanone O-{2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4 -trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzoyl}oxime, m.p. 128°-130° C. Subsequently, it is filtered evaporated to dryness under reduced pressure The residue is purified by chromatography on silica gel with n-hexane/diethyl ether (4:1) as the eluent

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.0 g of 3 hydroxypicolinic acid, 10 ml of N,N-dimethylformamide was added, and then 5.9 g of thionyl chloride was dropwise added thereto at a temperature of at most 10° C. The mixture was stirred at 0° C. for 30 minutes. To the reaction solution, 30 ml of chloroform was added, and the mixture was further stirred at 0° C. for 15 minutes. Then, a solution prepared by dissolving 5.0 g of diethyl ketone oxime in 50 ml of chloroform was dropwise added thereto at 0° C., and the mixture was stirred for 30 minutes. Then, 7.9 g of pyridine was dropwise added thereto. Then, the reaction solution was stirred at 0° C. for one hour and at room temperature for one day. The reaction solution was poured into water and extracted with ethyl acetate. Then, the extract was washed with a saturated sodium hydrogencarbonate aqueous solution and with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue thereby obtained was purified by silica gel column chromatography by using as a developing solvent a mixture of hexane/ethyl ether to obtain 6.5 g of the above identified compound as slightly yellow transparent viscous liquid. at a temperature of at most 10° C the mixture was further stirred at 0° C. for 15 minutes Then, a solution prepared was dropwise added at 0° C., and the mixture was stirred for 30 minutes Then, the reaction solution was stirred at 0° C. for one hour and at room temperature for one day extracted with ethyl acetate Then, the extract was washed with a saturated sodium hydrogencarbonate aqueous solution and with a saturated sodium chloride aqueous solution dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure the residue thereby obtained was purified by silica gel column chromatography a mixture of hexane/ethyl ether to obtain 6.5 g of the

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of pentan-3-one oxime (6.00 g) in dimethylformamide (30 ml) was added sodium hydride (60% oil suspension, 2.37 g) under ice cooling. After 15 minutes, to the above mixture was added dropwise 1-fluoro-2-nitrobenzene (5.98 g) in dimethylformamide (30 ml). The mixture was stirred for 3 hours at ambient temperature and poured into a mixture of ice and water. The separated oil was extracted with diethyl ether. The organic layer was washed with water, dried over sodium sulfate and evaporated in vacuo to give pentan-3-one O-(2-nitrophenyl)oxime (10.51 g) as a brown oil. The separated oil was extracted with diethyl ether The organic layer was washed with water dried over sodium sulfate evaporated in vacuo

Conditions: temp:0.00; pressure:0.00; stir: