1-ethyl-2,2-dimethylpiperazine

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-ethyl,2,2-dimethylpiperazine. 1H NMR (400 MHz, ACETONITRILE-d3) δ ppm 0.79-1.20 (m, 9 H) 2.36-2.48 (m, 5 H) 2.59 (d, J=6.06 Hz, 2 H) 3.15 (br. s., 1 H) 3.44 (br. s., 2 H) 3.69 (br. s., 1H) 7.53-7.59 (m, 1 H) 7.60-7.63 (m, 1 H) 7.63-7.66 (m, 1 H) 7.75 (s, 1 H) 8.01 (br. s., 2H) 8.42 (br. s., 1 H); ESI-MS m/z [M+H]+ 445.3.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-ethyl,2,2-dimethylpiperazine. 1H NMR (400 MHz, ACETONITRILE-d3) δ ppm 0.79-1.20 (m, 9H) 2.36-2.48 (m, 5H) 2.59 (d, J=6.06 Hz, 2H) 3.15 (br. s., 1H) 3.44 (br. s., 2H) 3.69 (br. s., 1H) 7.53-7.59 (m, 1H) 7.60-7.63 (m, 1H) 7.63-7.66 (m, 1H) 7.75 (s, 1H) 8.01 (br. s., 2H) 8.42 (br. s., 1H); ESI-MS m/z [M+H]+ 445.3.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-ethyl,2,2-dimethylpiperazine. 1H NMR (400 MHz, ACETONITRILE-d3) δ ppm 0.79-1.20 (m, 9 H) 2.36-2.48 (m, 5 H) 2.59 (d, J=6.06 Hz, 2 H) 3.15 (br. s., 1 H) 3.44 (br. s., 2 H) 3.69 (br. s., 1H) 7.53-7.59 (m, 1 H) 7.60-7.63 (m, 1 H) 7.63-7.66 (m, 1 H) 7.75 (s, 1 H) 8.01 (br. s., 2H) 8.42 (br. s., 1 H); ESI-MS m/z [M+H]+ 445.3.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-ethyl,2,2-dimethylpiperazine. 1H NMR (400 MHz, ACETONITRILE-d3) δ ppm 0.79-1.20 (m, 9H) 2.36-2.48 (m, 5H) 2.59 (d, J=6.06 Hz, 2H) 3.15 (br. s., 1H) 3.44 (br. s., 2H) 3.69 (br. s., 1H) 7.53-7.59 (m, 1H) 7.60-7.63 (m, 1H) 7.63-7.66 (m, 1H) 7.75 (s, 1H) 8.01 (br. s., 2H) 8.42 (br. s., 1H); ESI-MS m/z [M+H]+ 445.3.