4-methyl-4,7-diazaspiro[2.5]octane

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-methyl-4,7-diazaspiro[2.5]octane. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.58-1.34 (m, 4 H) 2.33 (d, J=2.27 Hz, 3 H) 2.91 (s, 3 H) 3.31-3.85 (m, 6 H) 7.62 (d, J=7.83 Hz, 1 H) 7.70-7.78 (m, 1 H) 7.82-8.75 (m, 4 H). ESI-MS m/z [M+H]+ 447.3.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-methyl-4,7-diazaspiro[2.5]octane. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.58-1.34 (m, 4H) 2.33 (d, J=2.27 Hz, 3H) 2.91 (s, 3H) 3.31-3.85 (m, 6H) 7.62 (d, J=7.83 Hz, 1H) 7.70-7.78 (m, 1H) 7.82-8.75 (m, 4H). ESI-MS m/z [M+H]+ 447.3.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-methyl-4,7-diazaspiro[2.5]octane. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.58-1.34 (m, 4 H) 2.33 (d, J=2.27 Hz, 3 H) 2.91 (s, 3 H) 3.31-3.85 (m, 6 H) 7.62 (d, J=7.83 Hz, 1 H) 7.70-7.78 (m, 1 H) 7.82-8.75 (m, 4 H). ESI-MS m/z [M+H]+ 447.3.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-methyl-4,7-diazaspiro[2.5]octane. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.58-1.34 (m, 4H) 2.33 (d, J=2.27 Hz, 3H) 2.91 (s, 3H) 3.31-3.85 (m, 6H) 7.62 (d, J=7.83 Hz, 1H) 7.70-7.78 (m, 1H) 7.82-8.75 (m, 4H). ESI-MS m/z [M+H]+ 447.3.