methyl 2-(difluoromethyl)-4-hydroxybenzoate

Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To methyl 2-(difluoromethyl)-4-(methoxymethoxy)benzoate (720 mg) were added 2N hydrochloric acid (6 ml) and ethanol (6 ml), and the mixture was stirred at 80° C. for 3 hours. The mixture was cooled to room temperature, and water was added thereto, and extracted with ethyl acetate. To the extract was added a saturated aqueous sodium chloride solution, and the mixture was dried over sodium sulfate, filtered, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (500 mg). The mixture was cooled to room temperature extracted with ethyl acetate To the extract was added a saturated aqueous sodium chloride solution the mixture was dried over sodium sulfate filtered concentrated under reduced pressure The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)