sodium;2-propylpentanoate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a 3-L round-bottomed flask was placed valproic acid (144 g, 1 mole) and 40% NaOH aqueous solution (100 g, 1 mole). The resulting solution was then put on a rotavaper, applied vacuum, and heated up slowly (e.g., water bath temperature from room temperature to 95° C.) to remove the water. Upon completion of the water removal, the reaction mixture was allowed to cool down to room temperature to obtain sodium valproate (166 g, 100%). In a 3-L round-bottomed flask was placed to remove the water Upon completion of the water removal

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 166 g (1 mole) sodium valproate and 90 g (moisture content<5%, 0.09 mole) a α-cyclodextrin are blended and 20 mL water is added. The ingredients are thoroughly kneaded, and the product is obtained by drying and grinding as described in Example 1. The moisture absorption after 24 hour storage at 40° C. under 75% relative humidity was found to be 43%, compared to 70% and 47% of sodium valproate itself and of the product obtained in a similar way with lactose instead of a α-cyclodextrin, respectively. The latter two were liquified. the product is obtained by drying grinding The moisture absorption after 24 hour storage at 40° C. under 75% relative humidity

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a 3-L round-bottomed flask was placed valproic acid (144 g, 1 mole) and 40% NaOH aqueous solution (100 g, 1 mole). The resulting solution was then put on a rotavaper, applied vacuum, and heated up slowly (e.g., water bath temperature from room temperature to 95° C.) to remove the water. Upon completion of the water removal, the reaction mixture was allowed to cool down to room temperature to obtain sodium valproate (166 g, 100%). In a 3-L round-bottomed flask was placed to remove the water Upon completion of the water removal