(S)-(4-chlorophenyl)-phenylmethanol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: An operation was carried out in the same manner as in Example 14, except that 0.29 mL (0.375 mmol) of 4-chlorophenylmagnesium bromide (1.4 mol/L) prepared from magnesium and 4-chlorobenzene bromide was used instead of the anhydrous THF solution of phenylmagnesium bromide. Thus, (S)-4-chlorobenzhydrol was obtained. The conversion rate of the raw material was 96%, while the enantiomeric excess was 92% ee.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: An operation was carried out in the same manner as in Example 14, except that 0.29 mL (0.375 mmol) of 4-chlorophenylmagnesium bromide (1.4 mol/L) prepared from magnesium and 4-chlorobenzene bromide was used instead of the anhydrous THF solution of phenylmagnesium bromide. Thus, (S)-4-chlorobenzhydrol was obtained. The conversion rate of the raw material was 96%, while the enantiomeric excess was 92% ee.