No renderable structure data available
CC(C)(C)OC(=O)OC(C(Cl)(Cl)Cl)ClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | tert-butyl 1,2,2,2-tetrachloroethyl carbonate |
|---|---|
| IUPAC Name | — |
| CAS Number | 98015-52-2 |
| Database ID | 2724535 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
tert-butyl 1,2,2,2-tetrachloroethyl carbonate (CAS 98015-52-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 2724535
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
11 reactions · 11 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f5fcda6afb844215bedc6367e9bef717Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-72085ca06d3a478db89ad885dac067a4Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f5fcda6afb844215bedc6367e9bef717Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f5fcda6afb844215bedc6367e9bef717Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 1.33 g (10 mmol) of L-aspartic acid in a dioxane/water (1:1) mixture (30 ml), 4.2 ml (30 mmol) of triethylamine are added, and the mixture is stirred until solution is complete (approximately 10 min). 2.85 g (10 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate are then added and the mixture is stirred for 6 hours at 20° C. 50 ml of water are then added and the mixture is extracted with 2×20 ml of ethyl acetate. The aqueous phase is acidified (pH 2-3) with NHCl, and then extracted with 3×30 ml of ethyl acetate. The extract is washed with saturated NaCl solution, dried over MgSO4 and evaporated. The product obtained is crystallised in ethyl acetate and petroleum ether. 1.4 g (60% yield) of the expected acid is obtained. ##STR60## (approximately 10 min) the mixture is stirred for 6 hours at 20° C the mixture is extracted with 2×20 ml of ethyl acetate extracted with 3×30 ml of ethyl acetate The extract is washed with saturated NaCl solution dried over MgSO4 evaporated The product obtained is crystallised in ethyl acetate
Source ID: ord-0c0661338a584907b09ee85e49489e40Conditions: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5 g (17.5 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate dissolved in 10 ml of THF are added at 0° C. to a solution of imidazole (1.2 g; 17.6 mmol) in THF (20 ml) in the presence of 5M aqueous potassium carbonate solution (5 ml). The mixture is stirred for 1 hour at 20° C., and the organic phase is decanted and washed with 10 ml of saturated aqueous NaCl solution. the organic phase is decanted washed with 10 ml of saturated aqueous NaCl solution
Source ID: ord-18ed9719ba5540d59af2fe55eab3dddbConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-72085ca06d3a478db89ad885dac067a4Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 1.33 g (10 mmol) of L-aspartic acid in a dioxane/water (1:1) mixture (30 ml), 4.2 ml (30 mmol) of triethylamine are added, and the mixture is stirred until solution is complete (approximately 10 min). 2.85 g (10 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate are then added and the mixture is stirred for 6 hours at 20° C. 50 ml of water are then added and the mixture is extracted with 2×20 ml of ethyl acetate. The aqueous phase is acidified (pH 2-3) with NHCl, and then extracted with 3×30 ml of ethyl acetate. The extract is washed with saturated NaCl solution, dried over MgSO4 and evaporated. The product obtained is crystallised in ethyl acetate and petroleum ether. 1.4 g (60% yield) of the expected acid is obtained. ##STR60## (approximately 10 min) the mixture is stirred for 6 hours at 20° C the mixture is extracted with 2×20 ml of ethyl acetate extracted with 3×30 ml of ethyl acetate The extract is washed with saturated NaCl solution dried over MgSO4 evaporated The product obtained is crystallised in ethyl acetate
Source ID: ord-0c0661338a584907b09ee85e49489e40Conditions: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5 g (17.5 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate dissolved in 10 ml of THF are added at 0° C. to a solution of imidazole (1.2 g; 17.6 mmol) in THF (20 ml) in the presence of 5M aqueous potassium carbonate solution (5 ml). The mixture is stirred for 1 hour at 20° C., and the organic phase is decanted and washed with 10 ml of saturated aqueous NaCl solution. the organic phase is decanted washed with 10 ml of saturated aqueous NaCl solution
Source ID: ord-18ed9719ba5540d59af2fe55eab3dddbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 1.33 g (10 mmol) of L-aspartic acid in a dioxane/water (1:1) mixture (30 ml), 4.2 ml (30 mmol) of triethylamine are added, and the mixture is stirred until solution is complete (approximately 10 min). 2.85 g (10 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate are then added and the mixture is stirred for 6 hours at 20° C. 50 ml of water are then added and the mixture is extracted with 2×20 ml of ethyl acetate. The aqueous phase is acidified (pH 2-3) with NHCl, and then extracted with 3×30 ml of ethyl acetate. The extract is washed with saturated NaCl solution, dried over MgSO4 and evaporated. The product obtained is crystallised in ethyl acetate and petroleum ether. 1.4 g (60% yield) of the expected acid is obtained. ##STR60## (approximately 10 min) the mixture is stirred for 6 hours at 20° C the mixture is extracted with 2×20 ml of ethyl acetate extracted with 3×30 ml of ethyl acetate The extract is washed with saturated NaCl solution dried over MgSO4 evaporated The product obtained is crystallised in ethyl acetate
Source ID: ord-0c0661338a584907b09ee85e49489e40Conditions: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5 g (17.5 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate dissolved in 10 ml of THF are added at 0° C. to a solution of imidazole (1.2 g; 17.6 mmol) in THF (20 ml) in the presence of 5M aqueous potassium carbonate solution (5 ml). The mixture is stirred for 1 hour at 20° C., and the organic phase is decanted and washed with 10 ml of saturated aqueous NaCl solution. the organic phase is decanted washed with 10 ml of saturated aqueous NaCl solution
Source ID: ord-18ed9719ba5540d59af2fe55eab3dddbPubChem References
These sources are listed in the compound's public database record.
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