tert-butyl N-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]carbamate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: tert-butyl [(1S,2S)-2-(hydroxymethyl)cyclohexyl]carbamate (1.3 g, 5.68 mmol) was dissolved in dichloromethane (10 mL) and MsCl (0.52 mL, 6.75 mmol) was added drop wise at 0° C. Triethylamine (1 mL) was then added and the mixture stirred for 2 hours. The reaction mixture was quenched with ice and diluted in dichloromethane. Washed with a saturated solution of NaHCO3 and brine, dried and concentrated in vacuo to provide the tile compound as brown solid (1.8 g). MS (M+1): 308.16 The reaction mixture was quenched with ice diluted in dichloromethane Washed with a saturated solution of NaHCO3 and brine dried concentrated in vacuo

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: tert-butyl [(1S,2S)-2-(hydroxymethyl)cyclohexyl]carbamate (1.3 g, 5.68 mmol) was dissolved in dichloromethane (10 mL) and MsCl (0.52 mL, 6.75 mmol) was added drop wise at 0° C. Triethylamine (1 mL) was then added and the mixture stirred for 2 hours. The reaction mixture was quenched with ice and diluted in dichloromethane. Washed with a saturated solution of NaHCO3 and brine, dried and concentrated in vacuo to provide the tile compound as brown solid (1.8 g). MS (M+1): 308.16 The reaction mixture was quenched with ice diluted in dichloromethane Washed with a saturated solution of NaHCO3 and brine dried concentrated in vacuo

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: tert-butyl [(1S,2S)-2-(hydroxymethyl)cyclohexyl]carbamate (1.3 g, 5.68 mmol) was dissolved in dichloromethane (10 mL) and MsCl (0.52 mL, 6.75 mmol) was added drop wise at 0° C. Triethylamine (1 mL) was then added and the mixture stirred for 2 hours. The reaction mixture was quenched with ice and diluted in dichloromethane. Washed with a saturated solution of NaHCO3 and brine, dried and concentrated in vacuo to provide the tile compound as brown solid (1.8 g). MS (M+1): 308.16 The reaction mixture was quenched with ice diluted in dichloromethane Washed with a saturated solution of NaHCO3 and brine dried concentrated in vacuo

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of tert-butyl N-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]carbamate (1.3 g, 5.68 mmol) in dichloromethane (10 mL) was added drop wise with methane sulfonyl chloride (0.52 mL, 6.75 mmol) at 0° C. Triethylamine (1 mL) was then added and the mixture stirred for 2 hours. The reaction mixture was quenched with ice and diluted in dichloromethane. Washed with a saturated solution of NaHCO3 and brine, dried and concentrated in vacuo to provide the title compound as brown solid (1.8 g). MS (M+1): 308.16 The reaction mixture was quenched with ice diluted in dichloromethane Washed with a saturated solution of NaHCO3 and brine dried concentrated in vacuo