No renderable structure data available
CC(C)C1=C(C2=CC=CC=C2N1)C=OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-propan-2-yl-1H-indole-3-carbaldehyde |
|---|---|
| IUPAC Name | — |
| CAS Number | 95202-44-1 |
| Database ID | 13383890 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-propan-2-yl-1H-indole-3-carbaldehyde (CAS 95202-44-1) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 13383890
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9ab81b24bd324bd297688ed78f4b7ba4Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-300489d9e4284ef09c98ecfa7906be74Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2-isopropyl-1H-indole-3-carbaldehyde (Compound 39, 1.19 g, 6.4 mmol) in DMF (6.0 ml) was added benzyl bromide (1.5 ml, 12.8 mmol) and K2CO3 (2.65 g, 19.2 mmol). The mixture was stirred at room temperature for 24 h and was diluted with EtOAc, washed with H2O, brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes to yield 1-benzyl-2-isopropyl-1H-indole-3-carbaldehyde (Compound 40) as a light brown solid. washed with H2O, brine dried over Na2SO4 concentrated in vacuo The residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes
Source ID: ord-d5e35ff5c2ad49aa8a5d3b6dd41636c2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: POCl3 (0.86 ml, 9.4 mmol) was added dropwise to anhydrous DMF (4 ml) at 0° C. with stirring. After 30 min, this solution was added dropwise to a solution of 2-isopropyl-1H-indole (Compound 38, 1.24 g, 7.8 mmol) in DMF (16 ml) at 0° C. under argon. The reaction was stirred for 1 h while it warmed up to room temperature. The reaction was diluted with EtOAc, washed with aq. NaHCO3, brine, dried over Na2SO4, and concentrated in vacuo. The residual solid was washed with Et2O to yield 2-isopropyl-1H-indole-3-carbaldehyde (Compound 39) as a beige solid. The reaction was stirred for 1 h while it washed with aq. NaHCO3, brine dried over Na2SO4 concentrated in vacuo The residual solid was washed with Et2O
Source ID: ord-96aec4465b694a6d9142b168f3f585e7Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2-isopropyl-1H-indole-3-carbaldehyde (Compound 39, 1.19 g, 6.4 mmol) in DMF (6.0 ml) was added benzyl bromide (1.5 ml, 12.8 mmol) and K2CO3 (2.65 g, 19.2 mmol). The mixture was stirred at room temperature for 24 h and was diluted with EtOAc, washed with H2O, brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes to yield 1-benzyl-2-isopropyl-1H-indole-3-carbaldehyde (Compound 40) as a light brown solid. washed with H2O, brine dried over Na2SO4 concentrated in vacuo The residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes
Source ID: ord-d5e35ff5c2ad49aa8a5d3b6dd41636c2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: POCl3 (0.86 ml, 9.4 mmol) was added dropwise to anhydrous DMF (4 ml) at 0° C. with stirring. After 30 min, this solution was added dropwise to a solution of 2-isopropyl-1H-indole (Compound 38, 1.24 g, 7.8 mmol) in DMF (16 ml) at 0° C. under argon. The reaction was stirred for 1 h while it warmed up to room temperature. The reaction was diluted with EtOAc, washed with aq. NaHCO3, brine, dried over Na2SO4, and concentrated in vacuo. The residual solid was washed with Et2O to yield 2-isopropyl-1H-indole-3-carbaldehyde (Compound 39) as a beige solid. The reaction was stirred for 1 h while it washed with aq. NaHCO3, brine dried over Na2SO4 concentrated in vacuo The residual solid was washed with Et2O
Source ID: ord-96aec4465b694a6d9142b168f3f585e7Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: POCl3 (0.86 ml, 9.4 mmol) was added dropwise to anhydrous DMF (4 ml) at 0° C. with stirring. After 30 min, this solution was added dropwise to a solution of 2-isopropyl-1H-indole (Compound 38, 1.24 g, 7.8 mmol) in DMF (16 ml) at 0° C. under argon. The reaction was stirred for 1 h while it warmed up to room temperature. The reaction was diluted with EtOAc, washed with aq. NaHCO3, brine, dried over Na2SO4, and concentrated in vacuo. The residual solid was washed with Et2O to yield 2-isopropyl-1H-indole-3-carbaldehyde (Compound 39) as a beige solid. The reaction was stirred for 1 h while it washed with aq. NaHCO3, brine dried over Na2SO4 concentrated in vacuo The residual solid was washed with Et2O
Source ID: ord-96aec4465b694a6d9142b168f3f585e7Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-300489d9e4284ef09c98ecfa7906be74Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2-isopropyl-1H-indole-3-carbaldehyde (Compound 39, 1.19 g, 6.4 mmol) in DMF (6.0 ml) was added benzyl bromide (1.5 ml, 12.8 mmol) and K2CO3 (2.65 g, 19.2 mmol). The mixture was stirred at room temperature for 24 h and was diluted with EtOAc, washed with H2O, brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes to yield 1-benzyl-2-isopropyl-1H-indole-3-carbaldehyde (Compound 40) as a light brown solid. washed with H2O, brine dried over Na2SO4 concentrated in vacuo The residue was purified by flash chromatography on silica gel eluting with 0-30% EtOAc-hexanes
Source ID: ord-d5e35ff5c2ad49aa8a5d3b6dd41636c2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: POCl3 (0.86 ml, 9.4 mmol) was added dropwise to anhydrous DMF (4 ml) at 0° C. with stirring. After 30 min, this solution was added dropwise to a solution of 2-isopropyl-1H-indole (Compound 38, 1.24 g, 7.8 mmol) in DMF (16 ml) at 0° C. under argon. The reaction was stirred for 1 h while it warmed up to room temperature. The reaction was diluted with EtOAc, washed with aq. NaHCO3, brine, dried over Na2SO4, and concentrated in vacuo. The residual solid was washed with Et2O to yield 2-isopropyl-1H-indole-3-carbaldehyde (Compound 39) as a beige solid. The reaction was stirred for 1 h while it washed with aq. NaHCO3, brine dried over Na2SO4 concentrated in vacuo The residual solid was washed with Et2O
Source ID: ord-96aec4465b694a6d9142b168f3f585e7PubChem References
These sources are listed in the compound's public database record.
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