ethyl 2-oxo-2-(4-oxooxan-3-yl)acetate

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Ethyl 2-oxo-2-(4-oxotetrahydro-2H-pyran-3-yl)acetate (272 mg, 19%) was synthesised from tetrahydro-4H-pyran-4-one (1 ml, 10.83 mmol) and ethyl 2-chloro-2-oxoacetate (0.808 ml, 7.22 mmol) by the general procedure for the preparation of diketones. MS (ES−) m/z 199.1 (M−H)−

Conditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (418 mg, 1.36 mmol) and potassium carbonate (469 mg, 3.40 mmol) in EtOH (8mL) were stirred for 10min at 50° C. Ethyl 2-oxo-2-(4-oxotetrahydro-2H-pyran-3-yl)acetate (272 mg, 1.36 mmol) was added slowly and the reaction was stirred at 50° C. over night. The crude product was partitioned between DCM and water. The organic phase was dried and solvent evaporated and used as such in the next step. MS (ES+) m/z 410.0 (M+H)+ The crude product was partitioned between DCM and water The organic phase was dried solvent evaporated