No renderable structure data available
CCS(=O)(=O)NCCCCCCCC(=O)OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 8-(ethylsulfonylamino)octanoic acid |
|---|---|
| IUPAC Name | — |
| CAS Number | 844681-29-4 |
| Database ID | 21103229 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
8-(ethylsulfonylamino)octanoic acid (CAS 844681-29-4) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 21103229
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-805c29829e4e46e8a4c593721972ebb1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-3838e271a9c44c758886b8d55b565ebbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-3838e271a9c44c758886b8d55b565ebbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-ae31607607244fe2b8f8e2d80d12d7f8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-86e7507dbec247bd9c4c26f229db5248Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-61306cc242ae4b8896c94c35ab722da1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-61306cc242ae4b8896c94c35ab722da1Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-805c29829e4e46e8a4c593721972ebb1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-b4baf329c40f4b1f964992a85f5da5e1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0–5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7–8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1–2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). 1H NMR (DMSO-d6): 11.9 (1H, s); 6.96 (1H, t, J=6 Hz); 2.96 (2H, q, J=7.1); 2.88 (2H, q, J=6.6); 2.2 (2H, t, J=7.3); 1.45 (4H, m); 1.26 (6H, m); 1.18 (3H, t, J=7.3). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1–2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-872bfeb0b0ba49698f5da157e4508b9cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-3838e271a9c44c758886b8d55b565ebbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethanesulfonyl chloride (1.5 ml, 15.7 mmol) in dioxane (5 ml) was added to a solution of 8-aminooctanoic acid (1 g, 6.28 mmol) in 1N NaOH (22 ml) and dioxane (5 ml), while stirring at 0° C.-5° C. The mixture was allowed to warm to room temperature and stirred for 3.5 minutes. During this period, at 1 hour intervals, the pH was adjusted to 7-8 by addition of 25% NaOH solution. The reaction mixture was washed with diethyl ether (30 ml). The pH was adjusted to 1-2 by addition of 1N HCl and the mixture was extracted with ethyl acetate (70 ml). The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether. The solid was collected by filtration and dried under vacuum affording 600 mg of the title compound (38% yield). stirred for 3.5 minutes During this period The reaction mixture was washed with diethyl ether (30 ml) The pH was adjusted to 1-2 by addition of 1N HCl the mixture was extracted with ethyl acetate (70 ml) The organic layer was dried over sodium sulfate concentrated The residue was triturated with a mixture of diethyl ether The solid was collected by filtration dried under vacuum
Source ID: ord-ae31607607244fe2b8f8e2d80d12d7f8PubChem References
These sources are listed in the compound's public database record.
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