2-(propan-2-ylideneamino)oxyethanol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: by using 2-isopropylideneaminooxy-ethanol and 2-bromopropionyl bromide there is obtained 2-isopropylideneaminooxy-ethyl 2-bromopropionate, nD20 1.4710.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: by using 2-isopropylideneaminooxy-ethanol and 2-bromopropionyl bromide there is obtained 2-isopropylideneaminooxy-ethyl 2-bromopropionate, nD20 1.4710.

Conditions: temp:85.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 11.0 g of 5,7-dihydro-6H-dibenz[c,e]-azepine-6-carbonitrile, 11.7 g of acetone (2-hydroxyethyl) oxime and 0.33 g of potassium cyanide is heated to 85° C. for 3 days. The reaction mixture, cooled to about 40° C., is treated with 100 ml of water and extracted twice with ethyl acetate. The extracts are washed three times with water and once each time with semi-saturated and saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residue is chromatographed on silica gel with acetone as the eluent, and there is obtained 2-[(isopropylideneamino)oxy]-ethyl 5,7-dihydro-6H-dibenz[c,e]azepine-6 carboximidate as an oil, mass spectrum m/e: M+337 (13), 281 (11), 237 (72), 194 (84), 179 (79), 165 (78), 100 (85), 56 (100). The reaction mixture, cooled to about 40° C. extracted twice with ethyl acetate The extracts are washed three times with water once each time with semi-saturated and saturated sodium chloride solution, dried over anhydrous sodium sulfate evaporated under reduced pressure The residue is chromatographed on silica gel with acetone as the eluent

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: by using 2-isopropylideneaminooxy-ethanol and 2-bromopropionyl bromide there is obtained 2-isopropylideneaminooxy-ethyl 2-bromopropionate, nD20 1.4710.