ethyl 3-amino-4,4-difluorobutanoate

Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Ethyl 4,4-difluoro-3-amino-butanoate prepared as in Step B (3.340 g, 20 mM) is dissolved in 1 M HCl (20 ml) and the mixture heated at 100° C. for 3 hours. The solvent is evaporated in vacuo. The oily residue is crystallized from ethanol/ether; 2.800 g of 4,4-difluoro-3-amino-butanoic acid, hydrochloride (yield 80%). Mp: 150° C. The solvent is evaporated in vacuo The oily residue is crystallized from ethanol/ether