2-methyloctan-1-ol

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 21.2 g (147 mmol) of (-)-2-methyloctanol were added an aqueous solution of 330 ml of water and 46.4 g of concentrated sulfuric acid, which was stirred to form an emulsion. To this emulsion was added dropwise 63.4 g (401 mmol) of potassium permaganate over 7 hours. Then, the reaction mixture was added with 51.5 g of sodium bisulfite and poured into 270 ml of ice water together with 70 ml of ice water and 200 ml of ether. After the separation into two layers, the reaction product was extracted from the aqueous layer with ether, which was further extracted with a 10% aqueous solution of sodium hydroxide, added with ice and further with a concentrated hydrochloric acid to adjust the pH to not more than 1. Thereafter, the extraction with chloroform on the aqueous layer was performed, which was washed with water, dried on magnesium sulfate and filtered. The filtrate was concentrated and distilled under a reduced pressure to obtain 16.5 g (yield: 71%) of a colorless and transparent liquid of (+)-2-methyl octanoic acid. to form an emulsion After the separation into two layers the reaction product was extracted from the aqueous layer with ether, which was further extracted with a 10% aqueous solution of sodium hydroxide added with ice and further with a concentrated hydrochloric acid Thereafter, the extraction with chloroform on the aqueous layer which was washed with water dried on magnesium sulfate filtered The filtrate was concentrated distilled under a reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 21.2 g (147 mmol) of (-)-2-methyloctanol were added an aqueous solution of 330 ml of water and 46.4 g of concentrated sulfuric acid, which was stirred to form an emulsion. To this emulsion was added dropwise 63.4 g (401 mmol) of potassium permaganate over 7 hours. Then, the reaction mixture was added with 51.5 g of sodium bisulfite and poured into 270 ml of ice water together with 70 ml of ice water and 200 ml of ether. After the separation into two layers, the reaction product was extracted from the aqueous layer with ether, which was further extracted with a 10% aqueous solution of sodium hydroxide, added with ice and further with a concentrated hydrochloric acid to adjust the pH to not more than 1. Thereafter, the extraction with chloroform on the aqueous layer was performed, which was washed with water, dried on magnesium sulfate and filtered. The filtrate was concentrated and distilled under a reduced pressure to obtain 16.5 g (yield: 71%) of a colorless and transparent liquid of (+)-2-methyl octanoic acid. to form an emulsion After the separation into two layers the reaction product was extracted from the aqueous layer with ether, which was further extracted with a 10% aqueous solution of sodium hydroxide added with ice and further with a concentrated hydrochloric acid Thereafter, the extraction with chloroform on the aqueous layer which was washed with water dried on magnesium sulfate filtered The filtrate was concentrated distilled under a reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 21.2 g (147 mmol) of (-)-2-methyloctanol were added 330 ml of water and 46.4 g of concentrated sulfuric acid with stirring to form an emulsion. To this emulsion was added dropwise 63.4 g (401 mmol) of potassium permanganate over 7 hours. The reaction liquid was added with 51.5 g of sodium hydrogen sulfite, 70 ml of ice water and 200 ml of ether and poured into 270 ml of ice water. After the separation of two layers, the reaction product was extracted from water layer with ether and further with a 10% aqueous solution of sodium hydroxide, which was added with ice and further with concentrated sulfuric acid to adjust pH to not more than 1. The reaction product was extracted from the water layer with chloroform, washed with water, dried on magnesium sulfate and filtered off, and then the filtrate was concentrated and distilled under a reduced pressure to obtain 16.5 g (yield 71%) of a colorless and transparent liquid of (+)-2 -methyloctanoic acid. to form an emulsion The reaction liquid After the separation of two layers the reaction product was extracted from water layer with ether and further with a 10% aqueous solution of sodium hydroxide, which was added with ice and further with concentrated sulfuric acid The reaction product was extracted from the water layer with chloroform washed with water dried on magnesium sulfate filtered off the filtrate was concentrated distilled under a reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: After 46.4 g of concentrated sulfuric acid and 21.2 g (147 mmol) of (-)-2-methyloctanol were added to 330 ml of water, 63.4 g (401 mmol) of potassium permanganate was added dropwise over 7.3 hours while the reaction temperature was held at 21°~28° C. The thus obtained reaction mixture was poured into 270 ml of ice water, added with 52 g of sodium hydrogen sulfite, adjusted to pH of not more than 1 with hydrochloric acid, extracted with ether and then extracted with a 10% aqueous solution of sodium hydroxide. This extract was added with hydrochloric acid to adjust pH to not more than 1 and again extracted with chloroform. The extract was washed with water, dried, concentrated and distilled under a reduced pressure (0.28 mmHg, 91°~94° C.) to obtain 15.3 g (yield 64%) of (+)-2-methyl octanoic acid. was added dropwise over 7.3 hours while the reaction temperature was held at 21°~28° C The thus obtained reaction mixture extracted with ether extracted with a 10% aqueous solution of sodium hydroxide This extract was added with hydrochloric acid again extracted with chloroform The extract was washed with water dried concentrated distilled under a reduced pressure (0.28 mmHg, 91°~94° C.)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: After 46.4 g of concentrated sulfuric acid and 21.2 g (147 mmol) of (-)-2-methyloctanol were added to 330 ml of water, 63.4 g (401 mmol) of potassium permanganate was added dropwise over 7.3 hours while the reaction temperature was held at 21°~28° C. The thus obtained reaction mixture was poured into 270 ml of ice water, added with 52 g of sodium hydrogen sulfite, adjusted to pH of not more than 1 with hydrochloric acid, extracted with ether and then extracted with a 10% aqueous solution of sodium hydroxide. This extract was added with hydrochloric acid to adjust pH to not more than 1 and again extracted with chloroform. The extract was washed with water, dried, concentrated and distilled under a reduced pressure (0.28 mmHg, 91°~94° C.) to obtain 15.3 g (yield 64%) of (+)-2-methyl octanoic acid. was added dropwise over 7.3 hours while the reaction temperature was held at 21°~28° C The thus obtained reaction mixture extracted with ether extracted with a 10% aqueous solution of sodium hydroxide This extract was added with hydrochloric acid again extracted with chloroform The extract was washed with water dried concentrated distilled under a reduced pressure (0.28 mmHg, 91°~94° C.)

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: After 46.4 g of concentrated sulfuric acid and 21.2 g (147 mmol) of (-)-2-methyloctanol were added to 330 ml of water, 63.4 g (401 mmol) of potassium permanganate was added dropwise over 7.3 hours while holding a reaction temperature at 21°-28° C. The thus obtained reaction mixture was poured into 270 ml of ice water, and 52 g of sodium bisulfite was added thereto. After pH was adjusted to not more than 1 with hydrochloric acid, the resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide. The extract was added with hydrochloric acid to adjust pH to not more than 1 and again extracted with chloroform. The thus obtained extract was washed with water, dried, concentrated and then distilled under a reduced pressure (0.28 mmHg, 91°-94° C.) to obtain 15.3 g (yield: 64%) of (+)-2-methyl octanoic acid. was added dropwise over 7.3 hours at 21°-28° C The thus obtained reaction mixture was added the resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide The extract was added with hydrochloric acid again extracted with chloroform The thus obtained extract was washed with water dried concentrated distilled under a reduced pressure (0.28 mmHg, 91°-94° C.)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: After 46.4 g of concentrated sulfuric acid and 21.2 g (147 mmol) of (-)-2-methyloctanol were added to 330 ml of water, 63.4 g (401 mmol) of potassium permanganate was added dropwise over 7.3 hours while holding a reaction temperature at 21°-28° C. The thus obtained reaction mixture was poured into 270 ml of ice water, and 52 g of sodium bisulfite was added thereto. After pH was adjusted to not more than 1 with hydrochloric acid, the resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide. The extract was added with hydrochloric acid to adjust pH to not more than 1 and again extracted with chloroform. The thus obtained extract was washed with water, dried, concentrated and then distilled under a reduced pressure (0.28 mmHg, 91°-94° C.) to obtain 15.3 g (yield: 64%) of (+)-2-methyl octanoic acid. was added dropwise over 7.3 hours at 21°-28° C The thus obtained reaction mixture was added the resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide The extract was added with hydrochloric acid again extracted with chloroform The thus obtained extract was washed with water dried concentrated distilled under a reduced pressure (0.28 mmHg, 91°-94° C.)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: After 46.4 g of concentrated sulfuric acid and 21.2 g (147 mmol) of (-)-2-methyloctanol were added to 330 ml of water, 63.4 g (401 mmol) of potassium permanganate was added dropwise over 7.3 hours while holding a reaction temperature at 21°-28° C. The thus obtained reaction mixture was poured into 270 ml of ice water, and 52 g of sodium bisulfite was added thereto. After pH was adjusted to not more than 1 with hydrochloric acid, the resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide. The extract was added with hydrochloric acid to adjust pH to not more than 1 and again extracted with chloroform. The thus obtained extract was washed with water, dried, concentrated and then distilled under a reduced pressure (0.28 mmHg, 91°-94° C.) to obtain 15.3 g (yield: 64%) of (+)-2-methyl octanoic acid. was added dropwise over 7.3 hours at 21°-28° C The thus obtained reaction mixture was added the resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide The extract was added with hydrochloric acid again extracted with chloroform The thus obtained extract was washed with water dried concentrated distilled under a reduced pressure (0.28 mmHg, 91°-94° C.)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 21.2 g (147 mmol) of (-)-2-methyloctanol were added an aqueous solution of 330 ml of water and 46.4 g of concentrated sulfuric acid, which was stirred to form an emulsion. To this emulsion was added dropwise 63.4 g (401 mmol) of potassium permaganate over 7 hours. Then, the reaction mixture was added with 51.5 g of sodium bisulfite and poured into 270 ml of ice water together with 70 ml of ice water and 200 ml of ether. After the separation into two layers, the reaction product was extracted from the aqueous layer with ether, which was further extracted with a 10% aqueous solution of sodium hydroxide, added with ice and further with a concentrated hydrochloric acid to adjust the pH to not more than 1. Thereafter, the extraction with chloroform on the aqueous layer was performed, which was washed with water, dried on magnesium sulfate and filtered. The filtrate was concentrated and distilled under a reduced pressure to obtain 16.5 g (yield: 71%) of a colorless and transparent liquid of (+)-2-methyl octanoic acid. to form an emulsion After the separation into two layers the reaction product was extracted from the aqueous layer with ether, which was further extracted with a 10% aqueous solution of sodium hydroxide added with ice and further with a concentrated hydrochloric acid Thereafter, the extraction with chloroform on the aqueous layer which was washed with water dried on magnesium sulfate filtered The filtrate was concentrated distilled under a reduced pressure