3-(2-methylpropyl)piperazin-2-one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of methyl 2-bromo-4-methylpentanoate (V, Example 3, 14.6 g.) and ethylenediamine (VI, 12.5 g.) in ethanol (250 ml.) is stirred at 20°-25° for 20 hours. The ethanol is removed under reduced pressure and the residual oil is partitioned between chloroform and aqueous sodium bicarbonate. The chloroform layer is separated and the chloroform is removed under reduced pressure to give an oil which is refluxed in DMF (20 ml.) for one hour. After removal of the DMF the residue is column chromatographed on silica gel eluting with chloroform-methanol (99/5). Appropriate fractions are pooled and concentrated to give a residue which is dissolved in ethyl acetate (150 ml.) and decolorized with charcoal. Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB gives the title compound, m.p. 75°-77°. The ethanol is removed under reduced pressure the residual oil is partitioned between chloroform and aqueous sodium bicarbonate The chloroform layer is separated the chloroform is removed under reduced pressure to give an oil which After removal of the DMF the residue chromatographed on silica gel eluting with chloroform-methanol (99/5) concentrated to give a residue which Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of methyl 2-bromo-4-methylpentanoate (V, Example 3, 14.6 g.) and ethylenediamine (VI, 12.5 g.) in ethanol (250 ml.) is stirred at 20°-25° for 20 hours. The ethanol is removed under reduced pressure and the residual oil is partitioned between chloroform and aqueous sodium bicarbonate. The chloroform layer is separated and the chloroform is removed under reduced pressure to give an oil which is refluxed in DMF (20 ml.) for one hour. After removal of the DMF the residue is column chromatographed on silica gel eluting with chloroform-methanol (99/5). Appropriate fractions are pooled and concentrated to give a residue which is dissolved in ethyl acetate (150 ml.) and decolorized with charcoal. Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB gives the title compound, m.p. 75°-77°. The ethanol is removed under reduced pressure the residual oil is partitioned between chloroform and aqueous sodium bicarbonate The chloroform layer is separated the chloroform is removed under reduced pressure to give an oil which After removal of the DMF the residue chromatographed on silica gel eluting with chloroform-methanol (99/5) concentrated to give a residue which Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of methyl 2-bromo-4-methylpentanoate (V, Example 3, 14.6 g.) and ethylenediamine (VI, 12.5 g.) in ethanol (250 ml.) is stirred at 20°-25° for 20 hours. The ethanol is removed under reduced pressure and the residual oil is partitioned between chloroform and aqueous sodium bicarbonate. The chloroform layer is separated and the chloroform is removed under reduced pressure to give an oil which is refluxed in DMF (20 ml.) for one hour. After removal of the DMF the residue is column chromatographed on silica gel eluting with chloroform-methanol (99/5). Appropriate fractions are pooled and concentrated to give a residue which is dissolved in ethyl acetate (150 ml.) and decolorized with charcoal. Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB gives the title compound, m.p. 75°-77°. The ethanol is removed under reduced pressure the residual oil is partitioned between chloroform and aqueous sodium bicarbonate The chloroform layer is separated the chloroform is removed under reduced pressure to give an oil which After removal of the DMF the residue chromatographed on silica gel eluting with chloroform-methanol (99/5) concentrated to give a residue which Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of methyl 2-bromo-4-methylpentanoate (V, Example 3, 14.6 g.) and ethylenediamine (VI, 12.5 g.) in ethanol (250 ml.) is stirred at 20°-25° for 20 hours. The ethanol is removed under reduced pressure and the residual oil is partitioned between chloroform and aqueous sodium bicarbonate. The chloroform layer is separated and the chloroform is removed under reduced pressure to give an oil which is refluxed in DMF (20 ml.) for one hour. After removal of the DMF the residue is column chromatographed on silica gel eluting with chloroform-methanol (99/5). Appropriate fractions are pooled and concentrated to give a residue which is dissolved in ethyl acetate (150 ml.) and decolorized with charcoal. Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB gives the title compound, m.p. 75°-77°. The ethanol is removed under reduced pressure the residual oil is partitioned between chloroform and aqueous sodium bicarbonate The chloroform layer is separated the chloroform is removed under reduced pressure to give an oil which After removal of the DMF the residue chromatographed on silica gel eluting with chloroform-methanol (99/5) concentrated to give a residue which Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of methyl 2-bromo-4-methylpentanoate (V, Example 3, 14.6 g.) and ethylenediamine (VI, 12.5 g.) in ethanol (250 ml.) is stirred at 20°-25° for 20 hours. The ethanol is removed under reduced pressure and the residual oil is partitioned between chloroform and aqueous sodium bicarbonate. The chloroform layer is separated and the chloroform is removed under reduced pressure to give an oil which is refluxed in DMF (20 ml.) for one hour. After removal of the DMF the residue is column chromatographed on silica gel eluting with chloroform-methanol (99/5). Appropriate fractions are pooled and concentrated to give a residue which is dissolved in ethyl acetate (150 ml.) and decolorized with charcoal. Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB gives the title compound, m.p. 75°-77°. The ethanol is removed under reduced pressure the residual oil is partitioned between chloroform and aqueous sodium bicarbonate The chloroform layer is separated the chloroform is removed under reduced pressure to give an oil which After removal of the DMF the residue chromatographed on silica gel eluting with chloroform-methanol (99/5) concentrated to give a residue which Crystallization from ethyl acetate-SSB gives an oily solid which upon crystallization from ethyl acetate-SSB