No renderable structure data available
B(C1=C(C(=CC=C1)F)OC)(O)OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | (3-fluoro-2-methoxyphenyl)boronic acid |
|---|---|
| IUPAC Name | — |
| CAS Number | 762287-59-2 |
| Database ID | 21931617 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
(3-fluoro-2-methoxyphenyl)boronic acid (CAS 762287-59-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 21931617
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-11cf59867c5c4c13b2586c5f247a81c1Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e55c3c4b112b46b09e8bbb5c9d5233dbConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-1e8a6114a21f402089d49394f1cdf57dConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-11cf59867c5c4c13b2586c5f247a81c1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (S)-2-(1-((5-Bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (100 mg, 0.17 mmol) was treated with (3-fluoro-2-methoxyphenyl)boronic acid (69 mg, 0.4 mmol), sodium carbonate (43 mg, 0.4 mmols) and bis(triphenylphosphine)palladium(II) dichloride (12 mg, 0.02 mmol) according to the method described in Preparation 62. The residue was purified using SP1® Purification System (0% to 100%, dichloromethane-ethyl acetate) to give 79 mg (73% yield) of the title compound. Purity 100%. described in Preparation 62 The residue was purified SP1® Purification System (0% to 100%, dichloromethane-ethyl acetate)
Source ID: ord-bb8697efd0e04abe97709931d1250b7bConditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 3-(7-chlorothieno[2,3-d]pyridazin-2-yl)-N-cyclopropyl-4-methylbenzamide (90 mg, 0.26 mmol), 3-fluoro-2-methoxyphenylboronic acid (67 mg, 0.39 mmol), Pd(PPh3)2Cl2 (18 mg, 0.03 mmol), and sodium carbonate (83 mg, 0.78 mmol) in a mixture of DME, ethanol and H2O (7:2:3, 2 ml) was heated to 150° C. for 15 min in the Emrys Optimizer® microwave. The mixture was diluted with MeOH and concentrated over SiO2. Column chromatography (MeOH/CH2Cl2=0→2%) afforded the desired product. Yield: 59 mg. MS (ESI, pos. ion) m/z: 434 (M+1). concentrated over SiO2
Source ID: ord-630e0ec370d34947ba1645a795b5e9dbConditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 3-(7-chlorothieno[2,3-d]pyridazin-2-yl)-N-cyclopropyl-4-methylbenzamide (90 mg, 0.26 mmol), 3-fluoro-2-methoxyphenylboronic acid (67 mg, 0.39 mmol), Pd(PPh3)2Cl2 (18 mg, 0.03 mmol), and sodium carbonate (83 mg, 0.78 mmol) in a mixture of DME, ethanol and H2O (7:2:3, 2 ml) was heated to 150° C. for 15 min in the Emrys Optimizer® microwave. The mixture was diluted with MeOH and concentrated over SiO2. Column chromatography (MeOH/CH2Cl2=0→2%) afforded the desired product. Yield: 59 mg. MS (ESI, pos. ion) m/z: 434 (M+1). concentrated over SiO2
Source ID: ord-630e0ec370d34947ba1645a795b5e9dbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared in analogy to example 25, from N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 25, intermediate a) and 3-fluoro-2-methoxyphenylboronic acid (CAS RN 762287-59-2) and using DMF as reaction solvent. Off-white solid (27%). MS (ESI): m/z=473.2 [M+H]+. as reaction solvent
Source ID: ord-7555814c210c4ca999a604c8b3fef583Conditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 3-(7-chlorothieno[2,3-d]pyridazin-2-yl)-N-cyclopropyl-4-methylbenzamide (90 mg, 0.26 mmol), 3-fluoro-2-methoxyphenylboronic acid (67 mg, 0.39 mmol), Pd(PPh3)2Cl2 (18 mg, 0.03 mmol), and sodium carbonate (83 mg, 0.78 mmol) in a mixture of DME, ethanol and H2O (7:2:3, 2 ml) was heated to 150° C. for 15 min in the Emrys Optimizer® microwave. The mixture was diluted with MeOH and concentrated over SiO2. Column chromatography (MeOH/CH2Cl2=0→2%) afforded the desired product. Yield: 59 mg. MS (ESI, pos. ion) m/z: 434 (M+1). concentrated over SiO2
Source ID: ord-d9b436b7e4904744ba60e825cd7e082dConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e55c3c4b112b46b09e8bbb5c9d5233dbConditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 3-(7-chlorothieno[2,3-d]pyridazin-2-yl)-N-cyclopropyl-4-methylbenzamide (90 mg, 0.26 mmol), 3-fluoro-2-methoxyphenylboronic acid (67 mg, 0.39 mmol), Pd(PPh3)2Cl2 (18 mg, 0.03 mmol), and sodium carbonate (83 mg, 0.78 mmol) in a mixture of DME, ethanol and H2O (7:2:3, 2 ml) was heated to 150° C. for 15 min in the Emrys Optimizer® microwave. The mixture was diluted with MeOH and concentrated over SiO2. Column chromatography (MeOH/CH2Cl2=0→2%) afforded the desired product. Yield: 59 mg. MS (ESI, pos. ion) m/z: 434 (M+1). concentrated over SiO2
Source ID: ord-d9b436b7e4904744ba60e825cd7e082dConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-1e8a6114a21f402089d49394f1cdf57dPubChem References
These sources are listed in the compound's public database record.
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