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O(C(C)C)C1C=CC=C(C=O)C=1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 3-ISOPROPOXY-BENZALDEHYDE |
|---|---|
| IUPAC Name | — |
| CAS Number | 75792-33-5 |
| Database ID | 712914 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
3-ISOPROPOXY-BENZALDEHYDE (CAS 75792-33-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 712914
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7a2ce767b6fe405e962459d559afe442Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4cdd5ad203894fc18e41f189eaf34c58Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9d6ec31641c74f7ca3bffe0b57630092Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7a2ce767b6fe405e962459d559afe442Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Isopropoxybenzaldehyde was prepared from 3-hydroxybenzaldehyde and isopropyl iodide analogous to the procedure described in Example 361. By using the procedure of Example 151 this aldehyde was transformed to 2-(3-isopropoxyphenyl)ethylamine, which was reacted with the product of Example 103, following the procedure of Example 105 to give the titled product.
Source ID: ord-e159b6f5e8b74ad6a5b27b503254cc59Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: EX-645A) 3-Hydroxybenzaldehyde (5.60 g, 45.9 mmol) and 2-iodopropane (7.86 g, 46.2 mmol) were dissolved in 50 mL of isopropanol. Potassium carbonate (20 g, 145 mmol) was added, and the mixture was heated to reflux for 8 h, at which time TLC analysis indicated that the reaction had gone to completion. Water was added to dissolve all solids, and the mixture was extracted with ether (3×). The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×), and finally with brine. The solution was dried over MgSO4, filtered, and evaporated to give 5.03 g (67%) of the desired 3-isopropoxybenzaldehyde product as a pale oil. 1H NMR (C6D6) δ9.62 (s, 1H), 7.29 (s, 1H), 7.03 (m, 1H), 6.91 (t, 1H), 6.84 (m, 1H), 4.03 (septet, 1H), 0.96 (d, 6H). the mixture was heated to reflux for 8 h, at which time TLC analysis to dissolve all solids the mixture was extracted with ether (3×) The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×) The solution was dried over MgSO4 filtered evaporated
Source ID: ord-51802622670e448c9bc229fc8f67d970Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: EX-645A) 3-Hydroxybenzaldehyde (5.60 g, 45.9 mmol) and 2-iodopropane (7.86 g, 46.2 mmol) were dissolved in 50 mL of isopropanol. Potassium carbonate (20 g, 145 mmol) was added, and the mixture was heated to reflux for 8 h, at which time TLC analysis indicated that the reaction had gone to completion. Water was added to dissolve all solids, and the mixture was extracted with ether (3×). The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×), and finally with brine. The solution was dried over MgSO4, filtered, and evaporated to give 5.03 g (67%) of the desired 3-isopropoxybenzaldehyde product as a pale oil. 1H NMR (C6D6) δ9.62 (s, 1H), 7.29 (s, 1H), 7.03 (m, 1H), 6.91 (t, 1H), 6.84 (m, 1H), 4.03 (septet, 1H), 0.96 (d, 6H). the mixture was heated to reflux for 8 h, at which time TLC analysis to dissolve all solids the mixture was extracted with ether (3×) The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×) The solution was dried over MgSO4 filtered evaporated
Source ID: ord-51802622670e448c9bc229fc8f67d970Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: EX-645A) 3-Hydroxybenzaldehyde (5.60 g, 45.9 mmol) and 2-iodopropane (7.86 g, 46.2 mmol) were dissolved in 50 mL of isopropanol. Potassium carbonate (20 g, 145 mmol) was added, and the mixture was heated to reflux for 8 h, at which time TLC analysis indicated that the reaction had gone to completion. Water was added to dissolve all solids, and the mixture was extracted with ether (3×). The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×), and finally with brine. The solution was dried over MgSO4, filtered, and evaporated to give 5.03 g (67%) of the desired 3-isopropoxybenzaldehyde product as a pale oil. 1H NMR (C6D6) δ9.62 (s, 1H), 7.29 (s, 1H), 7.03 (m, 1H), 6.91 (t, 1H), 6.84 (m, 1H), 4.03 (septet, 1H), 0.96 (d, 6H). the mixture was heated to reflux for 8 h, at which time TLC analysis to dissolve all solids the mixture was extracted with ether (3×) The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×) The solution was dried over MgSO4 filtered evaporated
Source ID: ord-cc108b6746dd478eb293b7b0db990264Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: EX-645A) 3-Hydroxybenzaldehyde (5.60 g, 45.9 mmol) and 2-iodopropane (7.86 g, 46.2 mmol) were dissolved in 50 mL of isopropanol. Potassium carbonate (20 g, 145 mmol) was added. and the mixture was heated to reflux for 8 h, at which time TLC analysis indicated that the reaction had gone to completion. Water was added to dissolve all solids, and the mixture was extracted with ether (3×). The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×), and finally with brine. The solution was dried over MgSO4, filtered, and evaporated to give 5.03 g (67%) of the desired 3-isopropoxybenzaldehyde product as a pale oil. 1H NMR (C6D6) δ9.62 (s, 1H), 7.29 (s, 1H), 7.03 (m, 1H), 6.91 (t, 1H), 6.84 (m, 1H), 4.03 (septet, 1H), 0.96 (d, 6H). and the mixture was heated to reflux for 8 h, at which time TLC analysis to dissolve all solids the mixture was extracted with ether (3×) The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×) The solution was dried over MgSO4 filtered evaporated
Source ID: ord-a0d8b28ca56144a1a4a84e0c24096275Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: EX-645A) 3-Hydroxybenzaldehyde (5.60 g, 45.9 mmol) and 2-iodopropane (7.86 g, 46.2 mmol) were dissolved in 50 mL of isopropanol. Potassium carbonate (20 g, 145 mmol) was added. and the mixture was heated to reflux for 8 h, at which time TLC analysis indicated that the reaction had gone to completion. Water was added to dissolve all solids, and the mixture was extracted with ether (3×). The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×), and finally with brine. The solution was dried over MgSO4, filtered, and evaporated to give 5.03 g (67%) of the desired 3-isopropoxybenzaldehyde product as a pale oil. 1H NMR (C6D6) δ9.62 (s, 1H), 7.29 (s, 1H), 7.03 (m, 1H), 6.91 (t, 1H), 6.84 (m, 1H), 4.03 (septet, 1H), 0.96 (d, 6H). and the mixture was heated to reflux for 8 h, at which time TLC analysis to dissolve all solids the mixture was extracted with ether (3×) The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4×) The solution was dried over MgSO4 filtered evaporated
Source ID: ord-a0d8b28ca56144a1a4a84e0c24096275Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: EX-645A) 3-Hydroxybenzaldehyde (5.60 g, 45.9 mmol) and 2-iodopropane (7.86 g, 46.2 mmol) were dissolved in 50 mL of isopropanol. Potassium carbonate (20 g, 145 mmol) was added, and the mixture was heated to reflux for 8 h, at which time TLC analysis indicated that the reaction had gone to completion. Water was added to dissolve all solids, and the mixture was extracted with ether (3x). The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4x), and finally with brine. The solution was dried over MgSO4, filtered, and evaporated to give 5.03 g (67%) of the desired 3-isopropoxybenzaldehyde product as a pale oil. 1H NMR (C6D6) δ 9.62 (s, 1H), 7.29 (s, 1H), 7.03 (m, 1H), 6.91 (t, 1H), 6.84 (m, 1H), 4.03 (septet, 1H), 0.96 (d, 6H). the mixture was heated to reflux for 8 h, at which time TLC analysis to dissolve all solids the mixture was extracted with ether (3x) The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4x) The solution was dried over MgSO4 filtered evaporated
Source ID: ord-0e5684627b3747428380152ea872789aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: EX-645A) 3-Hydroxybenzaldehyde (5.60 g, 45.9 mmol) and 2-iodopropane (7.86 g, 46.2 mmol) were dissolved in 50 mL of isopropanol. Potassium carbonate (20 g, 145 mmol) was added, and the mixture was heated to reflux for 8 h, at which time TLC analysis indicated that the reaction had gone to completion. Water was added to dissolve all solids, and the mixture was extracted with ether (3x). The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4x), and finally with brine. The solution was dried over MgSO4, filtered, and evaporated to give 5.03 g (67%) of the desired 3-isopropoxybenzaldehyde product as a pale oil. 1H NMR (C6D6) δ 9.62 (s, 1H), 7.29 (s, 1H), 7.03 (m, 1H), 6.91 (t, 1H), 6.84 (m, 1H), 4.03 (septet, 1H), 0.96 (d, 6H). the mixture was heated to reflux for 8 h, at which time TLC analysis to dissolve all solids the mixture was extracted with ether (3x) The combined ether layer was washed with water, 2 M NaOH, again with water until clear (4x) The solution was dried over MgSO4 filtered evaporated
Source ID: ord-0e5684627b3747428380152ea872789aPubChem References
These sources are listed in the compound's public database record.
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