No renderable structure data available
OC1C=C(C(C(C)C)=CC=1C(C)=O)OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1-(2,4-Dihydroxy-5-isopropylphenyl)ethanone |
|---|---|
| IUPAC Name | — |
| CAS Number | 747414-17-1 |
| Database ID | 24773360 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1-(2,4-Dihydroxy-5-isopropylphenyl)ethanone (CAS 747414-17-1) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 24773360
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7501fd7dafff461eb0c9f6880714ca01Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4ce61914ce24471bad0505ab417c02feConditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a mixture of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-ethanone (3.2 g), acetonitrile (60 ml) and potassium carbonate (10.6 g) in a 250 ml single neck RB flask equipped with a reflux condenser and a guard tube was added benzyl bromide (9.1 ml). The reaction mixture was refluxed (90° C.) for 16 h. The progress of the reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf˜0.5). On completion, acetonitrile was removed under reduced pressure. Water (100 ml) was added to the residue obtained and the resulting mixture was extracted with ethyl acetate (200 ml). The organic layer was dried over sodium sulphate. The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product. equipped with a reflux condenser and a guard tube On completion, acetonitrile was removed under reduced pressure Water (100 ml) was added to the residue obtained the resulting mixture was extracted with ethyl acetate (200 ml) The organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product
Source ID: ord-767cb90e5d6f44768c944e823f55df3bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Isopropyl-benzene-1,3-diol (5.8 g) and boron trifluoride etherate (28.7 ml) were introduced into a 250 ml single neck RB flask equipped with a reflux condenser and an inlet for nitrogen atmosphere stirred at RT for 10 min. Acetic acid (4.55 ml) was added to the reaction mixture and stirred at 90° C. for 16 h. On completion, 10% sodium acetate (300 ml) was added to the reaction mixture which was stirred at RT for 4 h before. The reaction mixture was extracted with ethyl acetate (300 ml) and washed with sat. sodium bicarbonate (100 ml) and the organic layer was dried over sodium sulphate. The reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf˜0.5). The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 10% EtOAc/n-hexane). equipped with a reflux condenser and an inlet for nitrogen atmosphere stirred at 90° C. for 16 h was stirred at RT for 4 h before The reaction mixture was extracted with ethyl acetate (300 ml) washed with sat. sodium bicarbonate (100 ml) the organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 10% EtOAc/n-hexane)
Source ID: ord-16e81389dd924bfa9bc58c1304d6cf99Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a mixture of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-ethanone (3.2 g), acetonitrile (60 ml) and potassium carbonate (10.6 g) in a a 250 ml single neck RB flask equipped with a reflux condenser and a guard tube was added benzyl bromide (9.1 ml). The reaction mixture was refluxed (90° C.) for 16 h. The progress of the reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf-0.5). On completion, acetonitrile was removed under reduced pressure. Water (100 ml) was added to the residue obtained and the resulting mixture was extracted with ethyl acetate (200 ml). The organic layer was dried over sodium sulphate. The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product. equipped with a reflux condenser and a guard tube On completion, acetonitrile was removed under reduced pressure Water (100 ml) was added to the residue obtained the resulting mixture was extracted with ethyl acetate (200 ml) The organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product
Source ID: ord-f28ae47f52b64f1fad41f41e7692e7d9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Isopropyl-benzene-1,3-diol (5.8 g) and boron trifluoride etherate (28.7 ml) were introduced into a 250 ml single neck RB flask equipped with a reflux condenser and an inlet for nitrogen atmosphere stirred at RT for 10 min. Acetic acid (4.55 ml) was added to the reaction mixture and stirred at 90° C. for 16 h. On completion, 10% sodium acetate (300 ml) was added to the reaction mixture which was stirred at RT for 4 h before. The reaction mixture was extracted with ethyl acetate (300 ml) and washed with sat. sodium bicarbonate (100 ml) and the organic layer was dried over sodium sulphate. The reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf˜0.5). The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 10% EtOAc/n-hexane). equipped with a reflux condenser and an inlet for nitrogen atmosphere stirred at 90° C. for 16 h was stirred at RT for 4 h before The reaction mixture was extracted with ethyl acetate (300 ml) washed with sat. sodium bicarbonate (100 ml) the organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 10% EtOAc/n-hexane)
Source ID: ord-f78072d795b04c24945479981085c65fConditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Isopropyl-benzene-1,3-diol (1 eq) was taken up in BF3.OEt2 (6 eq) and acetic acid was added (2 eq). The solution was heated for 16 hours at 90° C. than allowed to cool to room temperature. The solution was added drop wise to 10% NaOAc (aq) and allowed to stand for 4 hours, before being extracted in to EtOAc. The organic phases were combined and washed with sat. NaHCO3 (aq), then dried over MgSO4, filtered and concentrated in vacuo. The residual oil was purified by column chromatography, eluting with dichloromethane, to give 1-(2,4-Dihydroxy-5-isopropyl-phenyl)-ethanone as a white solid. to cool to room temperature before being extracted in to EtOAc washed with sat. NaHCO3 (aq) dried over MgSO4 filtered concentrated in vacuo The residual oil was purified by column chromatography eluting with dichloromethane
Source ID: ord-f20b62205308431b9439cc1478fd3e3fConditions: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 1-(2,4-Dihydroxy-5-isopropyl-phenyl)-ethanone (1 eq) was dissolved in DMF and potassium carbonate (2.2 eq) then benzyl bromide (2.2 eq) were added. The suspension was heated, with stirring to 150° C., under nitrogen, for 16 hrs. The solution was cooled to room temperature and the mixture was poured into 1MHCl (aq) then extracted in to ethyl acetate. The organic phases were combined and washed again with 1MHCl (aq) then five times with brine solution. The organic phase was dried over MgSO4, filtered and concentrated in vacuo, to give a solid, which was purified by diethyl ether: hexane (1:1) trituration to give 1-(2,4-Bis-benzyloxy-5-isopropyl-phenyl)-ethanone. The suspension was heated The solution was cooled to room temperature the mixture was poured into 1MHCl (aq) then extracted in to ethyl acetate washed again with 1MHCl (aq) The organic phase was dried over MgSO4 filtered concentrated in vacuo to give a solid, which was purified by diethyl ether: hexane (1:1) trituration
Source ID: ord-49cf99a6076a434ab3e0224d816380f8Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a mixture of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-ethanone (3.2 g), acetonitrile (60 ml) and potassium carbonate (10.6 g) in a a 250 ml single neck RB flask equipped with a reflux condenser and a guard tube was added benzyl bromide (9.1 ml). The reaction mixture was refluxed (90° C.) for 16 h. The progress of the reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf˜0.5). On completion, acetonitrile was removed under reduced pressure. Water (100 ml) was added to the residue obtained and the resulting mixture was extracted with ethyl acetate (200 ml). The organic layer was dried over sodium sulphate. The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product. equipped with a reflux condenser and a guard tube On completion, acetonitrile was removed under reduced pressure Water (100 ml) was added to the residue obtained the resulting mixture was extracted with ethyl acetate (200 ml) The organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product
Source ID: ord-ac8a96014d2e418490ae4291d44d2cc4Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a mixture of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-ethanone (3.2 g), acetonitrile (60 ml) and potassium carbonate (10.6 g) in a a 250 ml single neck RB flask equipped with a reflux condenser and a guard tube was added benzyl bromide (9.1 ml). The reaction mixture was refluxed (90° C.) for 16 h. The progress of the reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf˜0.5). On completion, acetonitrile was removed under reduced pressure. Water (100 ml) was added to the residue obtained and the resulting mixture was extracted with ethyl acetate (200 ml). The organic layer was dried over sodium sulphate. The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product. equipped with a reflux condenser and a guard tube On completion, acetonitrile was removed under reduced pressure Water (100 ml) was added to the residue obtained the resulting mixture was extracted with ethyl acetate (200 ml) The organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product
Source ID: ord-ac8a96014d2e418490ae4291d44d2cc4Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Isopropyl-benzene-1,3-diol (5.8 g) and boron trifluoride etherate (28.7 ml) were introduced into a 250 ml single neck RB flask equipped with a reflux condenser and an inlet for nitrogen atmosphere stirred at RT for 10 min. Acetic acid (4.55 ml) was added to the reaction mixture and stirred at 90° C. for 16 h. On completion, 10% sodium acetate (300 ml) was added to the reaction mixture which was stirred at RT for 4 h before. The reaction mixture was extracted with ethyl acetate (300 ml) and washed with sat. sodium bicarbonate (100 ml) and the organic layer was dried over sodium sulphate. The reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf˜0.5). The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 10% EtOAc/n-hexane). equipped with a reflux condenser and an inlet for nitrogen atmosphere stirred at 90° C. for 16 h was stirred at RT for 4 h before The reaction mixture was extracted with ethyl acetate (300 ml) washed with sat. sodium bicarbonate (100 ml) the organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 10% EtOAc/n-hexane)
Source ID: ord-850862a089c34baf921c98344df02ee6Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a mixture of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-ethanone (3.2 g), acetonitrile (60 ml) and potassium carbonate (10.6 g) in a 250 ml single neck RB flask equipped with a reflux condenser and a guard tube was added benzyl bromide (9.1 ml). The reaction mixture was refluxed (90° C.) for 16 h. The progress of the reaction was monitored by TLC (10% EtOAc/n-hexane, product Rf˜0.5). On completion, acetonitrile was removed under reduced pressure. Water (100 ml) was added to the residue obtained and the resulting mixture was extracted with ethyl acetate (200 ml). The organic layer was dried over sodium sulphate. The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product. equipped with a reflux condenser and a guard tube On completion, acetonitrile was removed under reduced pressure Water (100 ml) was added to the residue obtained the resulting mixture was extracted with ethyl acetate (200 ml) The organic layer was dried over sodium sulphate The solvent was removed under reduced pressure to give a residue to which n-hexane (150 ml) was added to give the product
Source ID: ord-767cb90e5d6f44768c944e823f55df3bPubChem References
These sources are listed in the compound's public database record.
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