2-fluoro-1-isocyanato-4-methylbenzene

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 4-((3-aminophenyl)ethynyl)-1H-indazol-3-amine (50 mg, 0.2 mmol) was taken in 2 ml of tetrahydrofuran, reaction was set under nitrogen atmosphere. 2-fluoro-1-isocyanato-4-methylbenzene was taken in 1 ml of tetrahydrofuran and added dropwise to the solution of 4-((3-aminophenyl)ethynyl)-1H-indazol-3-amine in tetrahydrofuran. The reaction was stirred at room temperature for 30 min, loaded onto silica and columned to give 1-{3-[(3-amino-1H-indazol-4-yl)ethynyl]phenyl}-3-(2-fluoro-5-methylphenyl)urea. reaction

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 4-((3-aminophenyl)ethynyl)-1H-indazol-3-amine (50 mg, 0.2 mmol) was taken in 2 ml of tetrahydrofuran, reaction was set under nitrogen atmosphere. 2-fluoro-1-isocyanato-4-methylbenzene was taken in 1 ml of tetrahydrofuran and added dropwise to the solution of 4-((3-aminophenyl)ethynyl)-1H-indazol-3-amine in tetrahydrofuran. The reaction was stirred at room temperature for 30 min, loaded onto silica and columned to give 1-{3-[(3-amino-1H-indazol-4-yl)ethynyl]phenyl}-3-(2-fluoro-5-methylphenyl)urea. reaction