diethyl 2,2-difluoropropanedioate

Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Sodium hydroxide (0.90 g, 0.022 mol) was dissolved in 5 mL water followed by dilution with 25 mL ethanol and the solution was heated to 60° C. Diethyl difluoromalonate (2 g, 0.01 mol) was then added to the stirred reaction mixture. A white precipitate formed immediately. The mixture was stirred for another 45 min while maintaining the temperature at 60° C. The fine white precipitate was collected and dried at 45° C. for 18 h. Yield 1.84 g (99%). A white precipitate formed immediately while maintaining the temperature at 60° C The fine white precipitate was collected dried at 45° C. for 18 h