N,N'-di(propan-2-yl)propane-1,3-diamine

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To N,N'-diisopropyl propane-1,3-diamine (23.43 g) in methylene chloride was added p-nitrobenzenesulfonyl chloride (11.08 g, 0.05 mole) dropwise and the reaction stirred 2 hours. The reaction was filtered, stripped, the residue dissolved in diethyl ether, refiltered after washing with water and the contents of the filtrate chromatographed on dry column silica gel with ethyl acetate to provide 9.75 g of clear product as the free base. Preparation of hydrochloride salt gave 8.22 g, m.r. 183°-185° C. The reaction was filtered the residue dissolved in diethyl ether after washing with water the contents of the filtrate chromatographed on dry column silica gel with ethyl acetate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,4 Dimethoxybenzenesulfonyl chloride was reacted with N,N'-diisopropylpropane-1,3-diamine by procedures following those given in Example 1 and chromatographed on Dry-column alumina with 10% methanol/ethyl acetate to provide the title compound. Treatment of this material with isopropanol/HCl gave the hydrochloride salt, m.p. 132°-135° C. chromatographed on Dry-column alumina with 10% methanol/ethyl acetate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To N,N'-diisopropyl propane-1,3-diamine (23.43 g) in methylene chloride was added p-nitrobenzenesulfonyl chloride (11.08 g, 0.05 mole) dropwise and the reaction stirred 2 hours. The reaction was filtered, stripped, the residue dissolved in diethyl ether, refiltered after washing with water and the contents of the filtrate chromatographed on dry column silica gel with ethyl acetate to provide 9.75 g of clear product as the free base. Preparation of hydrochloride salt gave 8.22 g, m.r. 183°-185° C. The reaction was filtered the residue dissolved in diethyl ether after washing with water the contents of the filtrate chromatographed on dry column silica gel with ethyl acetate