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CCCN(CCC)CCCNChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | N',N'-dipropylpropane-1,3-diamine |
|---|---|
| IUPAC Name | — |
| CAS Number | 6345-82-0 |
| Database ID | 239005 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
N',N'-dipropylpropane-1,3-diamine (CAS 6345-82-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 239005
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c0b2f4cf9a304274b412f02c8b80f7bfConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-2029643686ee409aa4433ad95b95d881Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The compound (190 mg) obtained in Example 2-2 was dissolved in DMF (3.0 ml) and added with DCC (189 mg), HOBt (124 mg), and the compound (96.9 mg) obtained in Example 22-3, followed by stirring overnight at room temperature. After completion of the reaction, the solvent was distilled off and the residue was then dissolved in chloroform, followed by separating the solution into layers by the addition of 1 mol/l hydrochloric acid. The aqueous layer was made basic with a 1 mol/l sodium hydroxide aqueous solution. Then, the solution was subjected to extraction with chloroform. The extract was washed with saturated saline solution and the organic layer was then dried with anhydrous sodium sulfate. The solvent was distilled off. Subsequently, the residue was treated with hydrochloric acid and then purified through silica gel column chromatography (chloroform/methanol/water), thereby obtaining hydrochloride (84.8 mg) of the subject compound as a white solid. After completion of the reaction the solvent was distilled off the residue was then dissolved in chloroform by separating the solution into layers by the addition of 1 mol/l hydrochloric acid Then, the solution was subjected to extraction with chloroform The extract was washed with saturated saline solution the organic layer was then dried with anhydrous sodium sulfate The solvent was distilled off Subsequently, the residue was treated with hydrochloric acid purified through silica gel column chromatography (chloroform/methanol/water)
Source ID: ord-a504a55952ac48419e885f08320a12feConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The compound (2.67 g) obtained in Example 22-2 was dissolved in anhydrous methanol (2.0 ml) and then added with a 4 mol/l hydrogen chloride/dioxane solution (20.0 ml), followed by stirring at room temperature for 1.5 hours. After completion of the reaction, the solvent was distilled off. Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution and extracted with dichloromethane. The extract was washed with distilled water and saturated saline solution, and then the organic layer was dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off, thereby obtaining the subject compound (726 mg) as a pale-yellow liquid. After completion of the reaction the solvent was distilled off Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution extracted with dichloromethane The extract was washed with distilled water and saturated saline solution the organic layer was dried with anhydrous sodium sulfate Subsequently, the solvent was distilled off
Source ID: ord-170b7660b4e04f85ad463c9b965f1676Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c0b2f4cf9a304274b412f02c8b80f7bfConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c0b2f4cf9a304274b412f02c8b80f7bfConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The compound (190 mg) obtained in Example 2-2 was dissolved in DMF (3.0 ml) and added with DCC (189 mg), HOBt (124 mg), and the compound (96.9 mg) obtained in Example 22-3, followed by stirring overnight at room temperature. After completion of the reaction, the solvent was distilled off and the residue was then dissolved in chloroform, followed by separating the solution into layers by the addition of 1 mol/l hydrochloric acid. The aqueous layer was made basic with a 1 mol/l sodium hydroxide aqueous solution. Then, the solution was subjected to extraction with chloroform. The extract was washed with saturated saline solution and the organic layer was then dried with anhydrous sodium sulfate. The solvent was distilled off. Subsequently, the residue was treated with hydrochloric acid and then purified through silica gel column chromatography (chloroform/methanol/water), thereby obtaining hydrochloride (84.8 mg) of the subject compound as a white solid. After completion of the reaction the solvent was distilled off the residue was then dissolved in chloroform by separating the solution into layers by the addition of 1 mol/l hydrochloric acid Then, the solution was subjected to extraction with chloroform The extract was washed with saturated saline solution the organic layer was then dried with anhydrous sodium sulfate The solvent was distilled off Subsequently, the residue was treated with hydrochloric acid purified through silica gel column chromatography (chloroform/methanol/water)
Source ID: ord-a504a55952ac48419e885f08320a12feConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The compound (2.67 g) obtained in Example 22-2 was dissolved in anhydrous methanol (2.0 ml) and then added with a 4 mol/l hydrogen chloride/dioxane solution (20.0 ml), followed by stirring at room temperature for 1.5 hours. After completion of the reaction, the solvent was distilled off. Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution and extracted with dichloromethane. The extract was washed with distilled water and saturated saline solution, and then the organic layer was dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off, thereby obtaining the subject compound (726 mg) as a pale-yellow liquid. After completion of the reaction the solvent was distilled off Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution extracted with dichloromethane The extract was washed with distilled water and saturated saline solution the organic layer was dried with anhydrous sodium sulfate Subsequently, the solvent was distilled off
Source ID: ord-170b7660b4e04f85ad463c9b965f1676Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The compound (2.67 g) obtained in Example 22-2 was dissolved in anhydrous methanol (2.0 ml) and then added with a 4 mol/l hydrogen chloride/dioxane solution (20.0 ml), followed by stirring at room temperature for 1.5 hours. After completion of the reaction, the solvent was distilled off. Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution and extracted with dichloromethane. The extract was washed with distilled water and saturated saline solution, and then the organic layer was dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off, thereby obtaining the subject compound (726 mg) as a pale-yellow liquid. After completion of the reaction the solvent was distilled off Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution extracted with dichloromethane The extract was washed with distilled water and saturated saline solution the organic layer was dried with anhydrous sodium sulfate Subsequently, the solvent was distilled off
Source ID: ord-170b7660b4e04f85ad463c9b965f1676Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-2029643686ee409aa4433ad95b95d881Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The compound (190 mg) obtained in Example 2-2 was dissolved in DMF (3.0 ml) and added with DCC (189 mg), HOBt (124 mg), and the compound (96.9 mg) obtained in Example 22-3, followed by stirring overnight at room temperature. After completion of the reaction, the solvent was distilled off and the residue was then dissolved in chloroform, followed by separating the solution into layers by the addition of 1 mol/l hydrochloric acid. The aqueous layer was made basic with a 1 mol/l sodium hydroxide aqueous solution. Then, the solution was subjected to extraction with chloroform. The extract was washed with saturated saline solution and the organic layer was then dried with anhydrous sodium sulfate. The solvent was distilled off. Subsequently, the residue was treated with hydrochloric acid and then purified through silica gel column chromatography (chloroform/methanol/water), thereby obtaining hydrochloride (84.8 mg) of the subject compound as a white solid. After completion of the reaction the solvent was distilled off the residue was then dissolved in chloroform by separating the solution into layers by the addition of 1 mol/l hydrochloric acid Then, the solution was subjected to extraction with chloroform The extract was washed with saturated saline solution the organic layer was then dried with anhydrous sodium sulfate The solvent was distilled off Subsequently, the residue was treated with hydrochloric acid purified through silica gel column chromatography (chloroform/methanol/water)
Source ID: ord-ebb67e245ec34811952db654e8ce3b51Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The compound (2.67 g) obtained in Example 22-2 was dissolved in anhydrous methanol (2.0 ml) and then added with a 4 mol/l hydrogen chloride/dioxane solution (20.0 ml), followed by stirring at room temperature for 1.5 hours. After completion of the reaction, the solvent was distilled off. Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution and extracted with dichloromethane. The extract was washed with distilled water and saturated saline solution, and then the organic layer was dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off, thereby obtaining the subject compound (726 mg) as a pale-yellow liquid. After completion of the reaction the solvent was distilled off Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution extracted with dichloromethane The extract was washed with distilled water and saturated saline solution the organic layer was dried with anhydrous sodium sulfate Subsequently, the solvent was distilled off
Source ID: ord-9effc3af86fb4dc4b0b5ace4280fee08PubChem References
These sources are listed in the compound's public database record.
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