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CC(C)C1=CC=CC2=C1NC(=O)C2=OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 7-propan-2-yl-1H-indole-2,3-dione |
|---|---|
| IUPAC Name | — |
| CAS Number | 57816-97-4 |
| Database ID | 12272793 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
7-propan-2-yl-1H-indole-2,3-dione (CAS 57816-97-4) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 12272793
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4e699c144e034ba0b5be076aba4e65e5Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-66440fc54c524decb8c7d66e88bfce8dConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4e699c144e034ba0b5be076aba4e65e5Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4e699c144e034ba0b5be076aba4e65e5Conditions: temp:75.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 7-isopropylindoline-2,3-dione (23.8 g, 0.12 mol) was added to a stirred solution of glacial acetic acid (700 ml). To this solution was added, via additional funnel bromine (7.8 ml, 0.15 mol) in glacial acetic acid (300 ml) during 30 min. After the addition, the combined mixture was stirred at 75° C. for 3 hr, cooled, and extracted with EtOAc. The organic extracts were washed with brine, dried over MgSO4, and evaporated in vacuo; air dried to give (31.8 g, 94%) of crude product. 1H NMR (300 MHz, CDCl3) δ 8.04 (b, NH), 7.59 (dd 2H), 2.84 (m, 1H), 1.31 (d, 6H); ESI (+) MS m/e=269 (MH+), ESI (−) MS m/e=267 (MH−). After the addition cooled extracted with EtOAc The organic extracts were washed with brine dried over MgSO4 evaporated in vacuo air dried
Source ID: ord-d0b2e1e40f244db09d5cff7d7ff21480Conditions: temp:75.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 7-isopropylindoline-2,3-dione (23.8 g, 0.12 mol) was added to a stirred solution of glacial acetic acid (700 ml). To this solution was added, via additional funnel bromine (7.8 ml, 0.15 mol) in glacial acetic acid (300 ml) during 30 min. After the addition, the combined mixture was stirred at 75° C. for 3 hr, cooled, and extracted with EtOAc. The organic extracts were washed with brine, dried over MgSO4, and evaporated in vacuo; air dried to give (31.8 g, 94%) of crude product. 1H NMR (300 MHz, CDCl3) δ 8.04 (b, NH), 7.59 (dd 2H), 2.84 (m, 1H), 1.31 (d, 6H); ESI (+) MS m/e=269 (MH+), ESI (−) MS m/e=267 (MH−). After the addition cooled extracted with EtOAc The organic extracts were washed with brine dried over MgSO4 evaporated in vacuo air dried
Source ID: ord-d0b2e1e40f244db09d5cff7d7ff21480Conditions: temp:75.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of concentrated H2SO4 (210 ml) and H2O (50 ml), was added over 20 min (26.7 g, 0.13 mol) of 2-(hydroxyimino)-N-(2-isopropylphenyl)acetamide. The mixture was stirred at 75° C. for 2 hr, cooled and poured onto cracked ice. After standing for 15 min, it was extracted with EtOAc, washed with water, dried over MgSO4, and concentrated. Air drying afforded (23.8 g, 97%) of crude product). 1H NMR (300 MHz, CDCl3) δ 8.15 (b, NH), 7.49 (d, 2H), 7.11 (t, 1H), 2.87 (m, 1H), 1.30 (d, 6H); ESI (+) MS m/e=190 (MH+), ESI (−) MS m/e=188 (MH−). cooled poured After standing for 15 min it was extracted with EtOAc washed with water dried over MgSO4 concentrated Air drying
Source ID: ord-f21066985d05472bbff519aac4647420Conditions: temp:75.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of concentrated H2SO4 (210 ml) and H2O (50 ml), was added over 20 min (26.7 g, 0.13 mol) of 2-(hydroxyimino)-N-(2-isopropylphenyl)acetamide. The mixture was stirred at 75° C. for 2 hr, cooled and poured onto cracked ice. After standing for 15 min, it was extracted with EtOAc, washed with water, dried over MgSO4, and concentrated. Air drying afforded (23.8 g, 97%) of crude product). 1H NMR (300 MHz, CDCl3) δ 8.15 (b, NH), 7.49 (d, 2H), 7.11 (t, 1H), 2.87 (m, 1H), 1.30 (d, 6H); ESI (+) MS m/e=190 (MH+), ESI (−) MS m/e=188 (MH−). cooled poured After standing for 15 min it was extracted with EtOAc washed with water dried over MgSO4 concentrated Air drying
Source ID: ord-f21066985d05472bbff519aac4647420Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 7-isopropyl-1H-indole-2,3-dione (2.97 g, 15.7 mmol) in tetrahydrofuran (20 mL) was dropped 2.0 M solution of lithium borohydride in tetrahydrofuran (15 mL, 30 mmol). The mixture was heated at 90° C. for 4 hours. It was quenched with 5% HCl, followed by saturated sodium bicarbonate. It was extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated to dryness to provide a crude 7-isopropyl-1H-indole. To a solution of the crude 7-isopropyl-1H-indole in diethyl ether (40 mL) was dropped 2.0 M solution of oxalyl chloride in dichloromethane (15 mL, 30 mmol). After stirring at room temperature for 5 hours, it was evaporated to dryness. Ethanol was added to the residue and it was stirred at room temperature overnight. After the ethanol was evaporated, flash chromatography on silica gel provided 0.972 g (24%) of the title compound as solid. ESI (−) MS m/e=258 (MH−). It was quenched with 5% HCl It was extracted with ethyl acetate The extracts were dried over magnesium sulfate evaporated to dryness
Source ID: ord-3185225653ea4395934a36d2ac5c9980Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 7-isopropyl-1H-indole-2,3-dione (2.97 g, 15.7 mmol) in tetrahydrofuran (20 mL) was dropped 2.0 M solution of lithium borohydride in tetrahydrofuran (15 mL, 30 mmol). The mixture was heated at 90° C. for 4 hours. It was quenched with 5% HCl, followed by saturated sodium bicarbonate. It was extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated to dryness to provide a crude 7-isopropyl-1H-indole. To a solution of the crude 7-isopropyl-1H-indole in diethyl ether (40 mL) was dropped 2.0 M solution of oxalyl chloride in dichloromethane (15 mL, 30 mmol). After stirring at room temperature for 5 hours, it was evaporated to dryness. Ethanol was added to the residue and it was stirred at room temperature overnight. After the ethanol was evaporated, flash chromatography on silica gel provided 0.972 g (24%) of the title compound as solid. ESI (−) MS m/e=258 (MH−). It was quenched with 5% HCl It was extracted with ethyl acetate The extracts were dried over magnesium sulfate evaporated to dryness
Source ID: ord-3185225653ea4395934a36d2ac5c9980Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To concentrated sulfuric acid at 80° C. was added 2-hydroxyimino-N-(2-isopropyl-phenyl)-acetamide in several small portions over 10 minutes. After addition it was heated at 80° C. for 30 minutes., then poured into ice. Filtration, washing with water, and drying under vacuum over P2O5 provided 2.974 g (84%) of the title compound as a solid. ESI (−) MS m/e=188 (MH−). After addition it , then poured into ice Filtration washing with water drying under vacuum over P2O5
Source ID: ord-fed303f8340645ab8a55b2ebef99768fConditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To concentrated sulfuric acid at 80° C. was added 2-hydroxyimino-N-(2-isopropyl-phenyl)-acetamide in several small portions over 10 minutes. After addition it was heated at 80° C. for 30 minutes., then poured into ice. Filtration, washing with water, and drying under vacuum over P2O5 provided 2.974 g (84%) of the title compound as a solid. ESI (−) MS m/e=188 (MH−). After addition it , then poured into ice Filtration washing with water drying under vacuum over P2O5
Source ID: ord-fed303f8340645ab8a55b2ebef99768fPubChem References
These sources are listed in the compound's public database record.
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