No renderable structure data available
CC(=O)NC1=C(C=C(C=C1)N)FChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | N-(4-amino-2-fluorophenyl)acetamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 57165-12-5 |
| Database ID | 255648 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
N-(4-amino-2-fluorophenyl)acetamide (CAS 57165-12-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 255648
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a606dad7aa85420cae1438f7c71d5294Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-45f9d18a334b4a1ba230ff9eaed1ea69Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-8de97bc0801143b9b254fe67ff9aa691Conditions: temp:15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried. The product which has precipitated is then filtered off washed twice with 150 ml of water each time dried
Source ID: ord-af46820c16b94459930855801c4df6e6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 198 g (1 mol) of 1-acetylamino-2-fluoro-4-nitrobenzene are transferred into a stainless steel autoclave together with 510 ml of methanol, about 3 g of palladium-on-charcoal (5%) are added and catalytic reduction is carried out in the course of 4 hours at 50° C. under a hydrogen pressure of 15 bar. After the catalyst has been removed, 450 ml of methanol are distilled off from the reaction solution in vacuo, the product which has precipitated is filtered off with suction and the residue is washed with a little methanol and dried at 50°-60° C. in a vacuum cabinet. are added is carried out in the course of 4 hours at 50° C. under a hydrogen After the catalyst has been removed 450 ml of methanol are distilled off from the reaction solution in vacuo the product which has precipitated is filtered off with suction the residue is washed with a little methanol dried at 50°-60° C. in a vacuum cabinet
Source ID: ord-d99fe9a7fe2043418c24bdf86339d290Conditions: temp:15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried. The product which has precipitated is then filtered off washed twice with 150 ml of water each time dried
Source ID: ord-4acb91097a55474a9d82e95b0a27f20aConditions: temp:15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried. The product which has precipitated is then filtered off washed twice with 150 ml of water each time dried
Source ID: ord-4acb91097a55474a9d82e95b0a27f20aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 198 g (1 mol) of 1-acetylamino-2-fluoro-4-nitrobenzene are transferred into a stainless steel autoclave together with 510 ml of methanol, about 3 g of palladium-on-charcoal (5%) are added and catalytic reduction is carried out in the course of 4 hours at 50° C. under a hydrogen pressure of 15 bar. After the catalyst has been removed, 450 ml of methanol are distilled off from the reaction solution in vacuo, the product which has precipitated is filtered off with suction and the residue is washed with a little methanol and dried at 50°-60° C. in a vacuum cabinet. are added is carried out in the course of 4 hours at 50° C. under a hydrogen After the catalyst has been removed 450 ml of methanol are distilled off from the reaction solution in vacuo the product which has precipitated is filtered off with suction the residue is washed with a little methanol dried at 50°-60° C. in a vacuum cabinet
Source ID: ord-40574bfebfd848c6a0340bf2ca154c17Conditions: temp:15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried. The product which has precipitated is then filtered off washed twice with 150 ml of water each time dried
Source ID: ord-af46820c16b94459930855801c4df6e6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 198 g (1 mol) of 1-acetylamino-2-fluoro-4-nitrobenzene are transferred into a stainless steel autoclave together with 510 ml of methanol, about 3 g of palladium-on-charcoal (5%) are added and catalytic reduction is carried out in the course of 4 hours at 50° C. under a hydrogen pressure of 15 bar. After the catalyst has been removed, 450 ml of methanol are distilled off from the reaction solution in vacuo, the product which has precipitated is filtered off with suction and the residue is washed with a little methanol and dried at 50°-60° C. in a vacuum cabinet. are added is carried out in the course of 4 hours at 50° C. under a hydrogen After the catalyst has been removed 450 ml of methanol are distilled off from the reaction solution in vacuo the product which has precipitated is filtered off with suction the residue is washed with a little methanol dried at 50°-60° C. in a vacuum cabinet
Source ID: ord-d99fe9a7fe2043418c24bdf86339d290Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 198 g (1 mol) of 1-acetylamino-2-fluoro-4-nitrobenzene are transferred into a stainless steel autoclave together with 510 ml of methanol, about 3 g of palladium-on-charcoal (5%) are added and catalytic reduction is carried out in the course of 4 hours at 50° C. under a hydrogen pressure of 15 bar. After the catalyst has been removed, 450 ml of methanol are distilled off from the reaction solution in vacuo, the product which has precipitated is filtered off with suction and the residue is washed with a little methanol and dried at 50°-60° C. in a vacuum cabinet. are added is carried out in the course of 4 hours at 50° C. under a hydrogen After the catalyst has been removed 450 ml of methanol are distilled off from the reaction solution in vacuo the product which has precipitated is filtered off with suction the residue is washed with a little methanol dried at 50°-60° C. in a vacuum cabinet
Source ID: ord-d99fe9a7fe2043418c24bdf86339d290Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a606dad7aa85420cae1438f7c71d5294PubChem References
These sources are listed in the compound's public database record.
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