ethyl 2-cyanocyclopropane-1-carboxylate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 6.50 g (46.7 mmol) of the compound from Example 72A were introduced into 20 ml of methanol at RT, 46.7 ml (46.7 mmol) of a 1N aqueous sodium hydroxide solution were added, and the mixture was stirred at RT for 2 h. Concentrated hydrochloric acid was then added until the pH was 2, the mixture was extracted with diethyl ether, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue was taken up in 8.5 ml (117 mmol) of thionyl chloride and stirred at 65° C. for 4 h. Cooling was followed by concentration, and the residue was twice taken up in diethyl ether and again concentrated each time. The residue was introduced into 17 ml of dichloromethane, 3.43 g (35.1 mmol) of N,O-dimethylhydroxylamine hydrochloride and 9.8 ml (70.3 mmol) of triethylamine were added, and the mixture was stirred at RT overnight. Water was added, the phases were separated, two extractions with dichloromethane were carried out, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The crude product was purified by flash chromatography on silica gel (mobile phase: dichloromethane/methanol 9/1) to result in 1.72 g (24% of theory) of the title compound. the mixture was extracted with diethyl ether the combined organic phases were dried over sodium sulfate filtered concentrated stirred at 65° C. for 4 h Cooling was followed by concentration again concentrated each time were added the mixture was stirred at RT overnight the phases were separated two extractions with dichloromethane the combined organic phases were dried over sodium sulfate filtered concentrated The crude product was purified by flash chromatography on silica gel (mobile phase: dichloromethane/methanol 9/1)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 6.50 g (46.7 mmol) of the compound from Example 72A were introduced into 20 ml of methanol at RT, 46.7 ml (46.7 mmol) of a 1N aqueous sodium hydroxide solution were added, and the mixture was stirred at RT for 2 h. Concentrated hydrochloric acid was then added until the pH was 2, the mixture was extracted with diethyl ether, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue was taken up in 8.5 ml (117 mmol) of thionyl chloride and stirred at 65° C. for 4 h. Cooling was followed by concentration, and the residue was twice taken up in diethyl ether and again concentrated each time. The residue was introduced into 17 ml of dichloromethane, 3.43 g (35.1 mmol) of N,O-dimethylhydroxylamine hydrochloride and 9.8 ml (70.3 mmol) of triethylamine were added, and the mixture was stirred at RT overnight. Water was added, the phases were separated, two extractions with dichloromethane were carried out, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The crude product was purified by flash chromatography on silica gel (mobile phase: dichloromethane/methanol 9/1) to result in 1.72 g (24% of theory) of the title compound. the mixture was extracted with diethyl ether the combined organic phases were dried over sodium sulfate filtered concentrated stirred at 65° C. for 4 h Cooling was followed by concentration again concentrated each time were added the mixture was stirred at RT overnight the phases were separated two extractions with dichloromethane the combined organic phases were dried over sodium sulfate filtered concentrated The crude product was purified by flash chromatography on silica gel (mobile phase: dichloromethane/methanol 9/1)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 40.2 g (291 mmol) of potassium carbonate were introduced into 89 ml of DMF at RT, 9.6 ml (146 mmol) of acrylonitrile, 15.5 ml (146 mmol) of ethyl chloroacetate and 1.96 g (8.61 mmol) of benzyltriethylammonium chloride were added, and the mixture was stirred at RT for 3 days. Water was added, the mixture was extracted with diethyl ether, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue was purified by vacuum distillation. 6.50 g (30% of theory) of the title compound (boiling range: 63-66° C./0.9 mbar) and 1.41 g (7%) of the corresponding cis-isomer (boiling range: 85-89° C./0.9 mbar) were obtained. the mixture was extracted with diethyl ether the combined organic phases were dried over sodium sulfate filtered concentrated The residue was purified by vacuum distillation

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 6.50 g (46.7 mmol) of the compound from Example 72A were introduced into 20 ml of methanol at RT, 46.7 ml (46.7 mmol) of a 1N aqueous sodium hydroxide solution were added, and the mixture was stirred at RT for 2 h. Concentrated hydrochloric acid was then added until the pH was 2, the mixture was extracted with diethyl ether, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue was taken up in 8.5 ml (117 mmol) of thionyl chloride and stirred at 65° C. for 4 h. Cooling was followed by concentration, and the residue was twice taken up in diethyl ether and again concentrated each time. The residue was introduced into 17 ml of dichloromethane, 3.43 g (35.1 mmol) of N,O-dimethylhydroxylamine hydrochloride and 9.8 ml (70.3 mmol) of triethylamine were added, and the mixture was stirred at RT overnight. Water was added, the phases were separated, two extractions with dichloromethane were carried out, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The crude product was purified by flash chromatography on silica gel (mobile phase: dichloromethane/methanol 9/1) to result in 1.72 g (24% of theory) of the title compound. the mixture was extracted with diethyl ether the combined organic phases were dried over sodium sulfate filtered concentrated stirred at 65° C. for 4 h Cooling was followed by concentration again concentrated each time were added the mixture was stirred at RT overnight the phases were separated two extractions with dichloromethane the combined organic phases were dried over sodium sulfate filtered concentrated The crude product was purified by flash chromatography on silica gel (mobile phase: dichloromethane/methanol 9/1)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 40.2 g (291 mmol) of potassium carbonate were introduced into 89 ml of DMF at RT, 9.6 ml (146 mmol) of acrylonitrile, 15.5 ml (146 mmol) of ethyl chloroacetate and 1.96 g (8.61 mmol) of benzyltriethylammonium chloride were added, and the mixture was stirred at RT for 3 days. Water was added, the mixture was extracted with diethyl ether, and the combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue was purified by vacuum distillation. 6.50 g (30% of theory) of the title compound (boiling range: 63-66° C./0.9 mbar) and 1.41 g (7%) of the corresponding cis-isomer (boiling range: 85-89° C./0.9 mbar) were obtained. the mixture was extracted with diethyl ether the combined organic phases were dried over sodium sulfate filtered concentrated The residue was purified by vacuum distillation