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CCCNCC1=CC=C(C=C1)ClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | N-[(4-chlorophenyl)methyl]propan-1-amine |
|---|---|
| IUPAC Name | — |
| CAS Number | 55245-43-7 |
| Database ID | 580714 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
N-[(4-chlorophenyl)methyl]propan-1-amine (CAS 55245-43-7) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 580714
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-69738e4c5e0743e993d9a16a26c15aa8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 25.2 g. N-4-chlorobenzyl-N-propylamine in 150 ml. ethyl acetate was added to 150 ml. ethyl acetate under reflux whilst phosgene was passed through. The passage of phosgene was continued for 21/2 hours, after which the ethyl acetate was evaporated to give an oily product. Distillation gave N-4-chlorobenzyl-N-propylcarbamoyl chloride, an oil b.p. 162°-164° C./4.0 mm. Hg. 2 hours after which the ethyl acetate was evaporated to give an oily product Distillation
Source ID: ord-ad35cf32aea443fe924e917eded58cf6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 25.2 g. N-4-chlorobenzyl-N-propylamine in 150 ml. ethyl acetate was added to 150 ml. ethyl acetate under reflux whilst phosgene was passed through. The passage of phosgene was continued for 21/2 hours, after which the ethyl acetate was evaporated to give an oily product. Distillation gave N-4-chlorobenzyl-N-propylcarbamoyl chloride, an oil b.p. 162°-164° C./4.0 mm. Hg. 2 hours after which the ethyl acetate was evaporated to give an oily product Distillation
Source ID: ord-ad35cf32aea443fe924e917eded58cf6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 48.3 g. 4-chlorobenzyl chloride in 40 ml. acetonitrile was added to a mixture of 18 g. propylamine, 12.6 g. sodium hydroxide, 50 ml. acetonitrile and 30 ml. water. The mixture was shaken intermittently for 45 minutes. An exothermic reaction occurred and a white solid separated in the lower phase. After a period of four days the reaction mixture was poured into a liter of water and the organic phase isolated with ether. Distillation of the ethereal extract gave an oily product N-4-chlorobenzyl-N-propylamine, b.p. 101°-106° C./1.7-2.5 mm. Hg. An exothermic reaction a white solid separated in the lower phase After a period of four days the reaction mixture was poured into a liter of water the organic phase isolated with ether Distillation of the ethereal extract
Source ID: ord-677b5bd8748c4bfabb3ec1fba9aef0f3Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 48.3 g. 4-chlorobenzyl chloride in 40 ml. acetonitrile was added to a mixture of 18 g. propylamine, 12.6 g. sodium hydroxide, 50 ml. acetonitrile and 30 ml. water. The mixture was shaken intermittently for 45 minutes. An exothermic reaction occurred and a white solid separated in the lower phase. After a period of four days the reaction mixture was poured into a liter of water and the organic phase isolated with ether. Distillation of the ethereal extract gave an oily product N-4-chlorobenzyl-N-propylamine, b.p. 101°-106° C./1.7-2.5 mm. Hg. An exothermic reaction a white solid separated in the lower phase After a period of four days the reaction mixture was poured into a liter of water the organic phase isolated with ether Distillation of the ethereal extract
Source ID: ord-677b5bd8748c4bfabb3ec1fba9aef0f3Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 25.2 g. N-4-chlorobenzyl-N-propylamine in 150 ml. ethyl acetate was added to 150 ml. ethyl acetate under reflux whilst phosgene was passed through. The passage of phosgene was continued for 21/2 hours, after which the ethyl acetate was evaporated to give an oily product. Distillation gave N-4-chlorobenzyl-N-propylcarbamoyl chloride, an oil b.p. 162°-164° C./4.0 mm. Hg. 2 hours after which the ethyl acetate was evaporated to give an oily product Distillation
Source ID: ord-ad35cf32aea443fe924e917eded58cf6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 48.3 g. 4-chlorobenzyl chloride in 40 ml. acetonitrile was added to a mixture of 18 g. propylamine, 12.6 g. sodium hydroxide, 50 ml. acetonitrile and 30 ml. water. The mixture was shaken intermittently for 45 minutes. An exothermic reaction occurred and a white solid separated in the lower phase. After a period of four days the reaction mixture was poured into a liter of water and the organic phase isolated with ether. Distillation of the ethereal extract gave an oily product N-4-chlorobenzyl-N-propylamine, b.p. 101°-106° C./1.7-2.5 mm. Hg. An exothermic reaction a white solid separated in the lower phase After a period of four days the reaction mixture was poured into a liter of water the organic phase isolated with ether Distillation of the ethereal extract
Source ID: ord-677b5bd8748c4bfabb3ec1fba9aef0f3Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-69738e4c5e0743e993d9a16a26c15aa8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 25.2 g. N-4-chlorobenzyl-N-propylamine in 150 ml. ethyl acetate was added to 150 ml. ethyl acetate under reflux whilst phosgene was passed through. The passage of phosgene was continued for 21/2 hours, after which the ethyl acetate was evaporated to give an oily product. Distillation gave N-4-chlorobenzyl-N-propylcarbamoyl chloride, an oil b.p. 162°-164° C./4.0 mm. Hg. 2 hours after which the ethyl acetate was evaporated to give an oily product Distillation
Source ID: ord-bd96f1d19e3947468a944a5f697906c7Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 48.3 g. 4-chlorobenzyl chloride in 40 ml. acetonitrile was added to a mixture of 18 g. propylamine, 12.6 g. sodium hydroxide, 50 ml. acetonitrile and 30 ml. water. The mixture was shaken intermittently for 45 minutes. An exothermic reaction occurred and a white solid separated in the lower phase. After a period of 4 days the reaction mixture was poured into a liter of water and the organic phase isolated with ether. Distillation of the ethereal extract gave an oily product N-4-chlorobenzyl-N-propylamine, b.p. 101°-106° C./1.7-2.5 mm. Hg. An exothermic reaction a white solid separated in the lower phase After a period of 4 days the reaction mixture was poured into a liter of water the organic phase isolated with ether Distillation of the ethereal extract
Source ID: ord-c0fe75a6ac47414484e81e21bd332b5dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 25.2 g. N-4-chlorobenzyl-N-propylamine in 150 ml. ethyl acetate was added to 150 ml. ethyl acetate under reflux whilst phosgene was passed through. The passage of phosgene was continued for 21/2 hours, after which the ethyl acetate was evaporated to give an oily product. Distillation gave N-4-chlorobenzyl-N-propylcarbamoyl chloride, an oil b.p. 162°-164° C./4.0 mm. Hg. 2 hours after which the ethyl acetate was evaporated to give an oily product Distillation
Source ID: ord-8085f8d3cd504369b8bec926d1cfe3a2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 48.3 g 4-chlorobenzyl chloride in 40 ml. acetonitrile was added to a mixture of 18 g. propylamine, 12.6 g. sodium hydroxide, 50 ml. acetonitrile and 30 ml. water. The mixture was shaken intermittently for 45 minutes. An exothermic reaction occurred and a white solid separated in the lower phase. After a period of four days the reaction mixture was poured into a liter of water and the organic phase isolated with ether. Distillation of the ethereal extract gave an oily product N-4-chlorobenzyl-N-propylamine, m.p. 101°-106° C./1.7-2.5 mm. Hg. An exothermic reaction a white solid separated in the lower phase After a period of four days the reaction mixture was poured into a liter of water the organic phase isolated with ether Distillation of the ethereal extract
Source ID: ord-70abed123d91455e986166af9b1c4b34PubChem References
These sources are listed in the compound's public database record.
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