4,4-dimethylpent-2-ynoic acid

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 466 g of 4,4-dimethyl-2-pentynoic acid was blended with 3.5 liters of methylene chloride and stirred. 483 g of thionyl chloride was added thereto and reacted for 1 hour and then heated under reflux, whereby a hydrogen chloride gas was vigorously generated. After the reaction system was heated under reflux for 2 hours, the solvent was distilled away under reduced pressure. The product was a colorless liquid having a boiling point of about 70° C. at 20 mm Hg. Yield: 290 g, 54.3%. reacted for 1 hour heated under reflux After the reaction system was heated under reflux for 2 hours the solvent was distilled away under reduced pressure

Conditions: temp:5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 552 g of sodium hydroxide was dissolved in 3.0 liters of water and ice was added thereto to adjust the temperature to 5° C. or lower. Next, while stirring, dibromo-3-t-butyl-5-pyrazolidone was added thereto little by little while maintaining the temperature at 5° C. or lower. If the temperature would rise, ice was added, and acetonitrile was added in order to prevent foaming. After the completion of the reaction, 6 N hydrochloric acid was added to make the reaction solution acidic, and then the solution was subjected to extraction twice with ethyl acetate. ice was added to 5° C. ice was added was added the solution was subjected to extraction twice with ethyl acetate

Conditions: temp:5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 552 g of sodium hydroxide was dissolved in 3.0 liters of water and ice was added thereto to adjust the temperature to 5° C. or lower. Next, while stirring, dibromo-3-t-butyl-5-pyrazolidone was added thereto little by little while maintaining the temperature at 5° C. or lower. If the temperature would rise, ice was added, and acetonitrile was added in order to prevent foaming. After the completion of the reaction, 6 N hydrochloric acid was added to make the reaction solution acidic, and then the solution was subjected to extraction twice with ethyl acetate. ice was added to 5° C. ice was added was added the solution was subjected to extraction twice with ethyl acetate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 466 g of 4,4-dimethyl-2-pentynoic acid was blended with 3.5 liters of methylene chloride and stirred. 483 g of thionyl chloride was added thereto and reacted for 1 hour and then heated under reflux, whereby a hydrogen chloride gas was vigorously generated. After the reaction system was heated under reflux for 2 hours, the solvent was distilled away under reduced pressure. The product was a colorless liquid having a boiling point of about 70° C. at 20 mm Hg. Yield: 290 g, 54.3%. reacted for 1 hour heated under reflux After the reaction system was heated under reflux for 2 hours the solvent was distilled away under reduced pressure

Conditions: temp:5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 552 g of sodium hydroxide was dissolved in 3.0 liters of water and ice was added thereto to adjust the temperature to 5° C. or lower. Next, while stirring, dibromo-3-t-butyl-5-pyrazolidone was added thereto little by little while maintaining the temperature at 5° C. or lower. If the temperature would rise, ice was added, and acetonitrile was added in order to prevent foaming. After the completion of the reaction, 6 N hydrochloric acid was added to make the reaction solution acidic, and then the solution was subjected to extraction twice with ethyl acetate. ice was added to 5° C. ice was added was added the solution was subjected to extraction twice with ethyl acetate