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CCOC(=O)C1CSCN1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | ethyl 1,3-thiazolidine-4-carboxylate |
|---|---|
| IUPAC Name | — |
| CAS Number | 51977-21-0 |
| Database ID | 103574 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
ethyl 1,3-thiazolidine-4-carboxylate (CAS 51977-21-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 103574
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-8c905e0ad8f94eaeae6983e54d57bb7aConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-8c769543652e4da39495880e687e31a8Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-2f88b70bb45e4d59a6731fe409c78ea9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 3-(4-pentadecenylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is recrystallized from acetonitrile
Source ID: ord-d8d93525a0534249b649b99e88de8c61Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 4-(16-bromohexadecylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile to yield 3-[4-(16-bromohexadecylamino)benzoyl]-4-carbethoxythiazolidine. By means of the alkaline hydrolysis method of Example 10, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is recrystallized from acetonitrile
Source ID: ord-6849e788df9146de90621371583de0cdConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is crystallized from acetonitrile. By means of the alkaline hydrolysis method of Example 1, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is crystallized from acetonitrile By means of the alkaline hydrolysis method of Example 1 This acid is also prepared
Source ID: ord-8408e481869f486cbfd60bce4bb9ab27Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is crystallized from acetonitrile. By means of the alkaline hydrolysis method of Example 1, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is crystallized from acetonitrile By means of the alkaline hydrolysis method of Example 1 This acid is also prepared
Source ID: ord-8408e481869f486cbfd60bce4bb9ab27Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 4-(4-pentadecenylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is recrystallized from acetonitrile
Source ID: ord-e5dc31ffea4745cc8bbb28d2fb22a12bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile. By means of the alkaline hydrolysis method of Example 1, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is recrystallized from acetonitrile By means of the alkaline hydrolysis method of Example 1 This acid is also prepared
Source ID: ord-b7964c11b5f04165a73d39ad8d1f8a19Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile. By means of the alkaline hydrolysis method of Example 1, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is recrystallized from acetonitrile By means of the alkaline hydrolysis method of Example 1 This acid is also prepared
Source ID: ord-b7964c11b5f04165a73d39ad8d1f8a19Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 4-(16-bromohexadecylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile to yield 3-[4-(16-bromohexadecylamino)benzoyl]-4-carboxythiazolidine. By means of the alkaline hydrolysis method of Example 10, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is recrystallized from acetonitrile
Source ID: ord-f2cb39de5bb44b23ac25513cebce2033Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: One-tenth mole of 3-(4-pentadecenylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile. After 5 hours at 20° C. the solution is filtered evaporated to a white solid which is recrystallized from acetonitrile
Source ID: ord-d8d93525a0534249b649b99e88de8c61PubChem References
These sources are listed in the compound's public database record.
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