No renderable structure data available
C1=CC(=C(C(=C1)O)Cl)C#NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-chloro-3-hydroxybenzonitrile |
|---|---|
| IUPAC Name | — |
| CAS Number | 51786-11-9 |
| Database ID | 21436545 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-chloro-3-hydroxybenzonitrile (CAS 51786-11-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 21436545
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9d93bd9072ae42479a1b43abd088275bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. 1H NMR (400 MHz, CD3OD) δ: 7.18 (d, 1H), 7.26 (m, 2H) was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-14087eda22ef41ffbdd22b6150a09fdcConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. 1H NMR (400 MHz, CD3OD) δ: 7.18 (d, 1H), 7.26 (m, 2H) was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-14087eda22ef41ffbdd22b6150a09fdcConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-21425dcc9c6e475983e596b6a620121dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-21425dcc9c6e475983e596b6a620121dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-ada5673d3bfe4b2b954acd2604a1bd63Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxylammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-3228a409c4a9446ebecc30f3b3fc2962Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-ada5673d3bfe4b2b954acd2604a1bd63Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxylammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-3228a409c4a9446ebecc30f3b3fc2962Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9d93bd9072ae42479a1b43abd088275bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. 1H NMR (400 MHz, CD3OD) δ: 7.18 (d, 1H), 7.26 (m, 2H) was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-14087eda22ef41ffbdd22b6150a09fdcConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
Source ID: ord-21425dcc9c6e475983e596b6a620121dPubChem References
These sources are listed in the compound's public database record.
Request a Quote
Send the required specification, quantity, destination and intended use. The CATO team will review availability and respond.