6-hydroxy-6-methylheptan-2-one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Taking an overall evaluation of the second and third reaction (which simulate a plant operating with recycle but without recycling the hydroxyketone), a 2,6,6-trimethyl-2-cyanomethyltetrahydropyran yield of 52.9 mol % is obtained with respect to the 2-methyl-heptan-2-ol-6-one introduced into the reaction. As the hydroxyketone conversion during each test is about 80%, it is foreseeable that the overall pyran nitrile yield would rise to around 66 mol % if the unconverted hydroxyketone was also recycled. third reaction (which

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The distillation residue of the second reaction is again recycled for a third synthesis after adding a further 122.7 g of 94.5% 2-methyl-heptan-2-ol-6-one (0.80525 moles), 5.2853 g of 86% KOH and acetonitrile in the usual ratio. After the reaction, distillation gives 82.0 g of 2,6,6-trimethyl-2-cyanomethyltetrahydropyran (0.49099 moles) in the distillate, together with the unconverted hydroxyketone. The distillation residue of the second reaction is again recycled for a third synthesis After the reaction, distillation