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CC(=O)C1=C2C=CNC2=CC=C1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1-(1H-indol-4-yl)ethanone |
|---|---|
| IUPAC Name | — |
| CAS Number | 50614-86-3 |
| Database ID | 13004673 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1-(1H-indol-4-yl)ethanone (CAS 50614-86-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 13004673
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-010f17ca57d848f9b62d9e5ce88ff4a2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104°-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-8801d30994174d00877f81bdb97836c4Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-3e825c4744c24e299eecd3f54913631fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-3e825c4744c24e299eecd3f54913631fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-27429585c0d1425bbbbd254358ed9d1dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-27429585c0d1425bbbbd254358ed9d1dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104°-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-8801d30994174d00877f81bdb97836c4Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104°-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-8801d30994174d00877f81bdb97836c4Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-010f17ca57d848f9b62d9e5ce88ff4a2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-3e825c4744c24e299eecd3f54913631fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-27429585c0d1425bbbbd254358ed9d1dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Acetylindole (0.101 g) was refluxed in 5 mL of ethyl acetate. Sodium hydride (0.20 g, 60% oil dispersion) was added in portions to the refluxing solution until thin layer chromatography analysis showed complete consumption of the starting material. The reaction mixture was quenched with water and acidified to pH 3. The ethyl acetate layer was dried (magnesium sulfate) and concentrated to give a crude product. The crude material was chromatographed on silica gel, eluting with hexane/ethyl acetate to give 1-(1H-indol-4-yl)-1,3-butanedione (0.104 g), a compound of formula (11), m.p. 104°-105° C. consumption of the starting material The reaction mixture was quenched with water The ethyl acetate layer was dried (magnesium sulfate) concentrated to give a crude product The crude material was chromatographed on silica gel eluting with hexane/ethyl acetate
Source ID: ord-8801d30994174d00877f81bdb97836c4PubChem References
These sources are listed in the compound's public database record.
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