No renderable structure data available
CC1=C(C=C(C=C1Br)F)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 3-bromo-5-fluoro-2-methylaniline |
|---|---|
| IUPAC Name | — |
| CAS Number | 502496-36-8 |
| Database ID | 2737641 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
3-bromo-5-fluoro-2-methylaniline (CAS 502496-36-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 2737641
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7f23ef3558634da6a7f5806bc2afd55dConditions: temp:110.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To iron powder (325 mesh, 2.25 g, 40.3 mmol) in 30 ml water and 80 ml isopropanol was added commercially available 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (3.04 g, 13 mmol) in 45 ml isopropanol and NH4Cl (1.46 g, 27.3 mmol). The resulting mixture was heated at 110° C. for 2 h. After evaporation of most of the isopropanol the aq solution was extracted with ethyl acetate three times. The combined organic layers were washed with water and brine, dried over MgSO4, filtered and evaporated. The crude product was used without further purification in the next step. After evaporation of most of the isopropanol the aq solution was extracted with ethyl acetate three times The combined organic layers were washed with water and brine dried over MgSO4 filtered evaporated The crude product was used without further purification in the next step
Source ID: ord-e6322d2c07c0442eb0a7e6b983a5a71aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Bromo-5-fluoro-2-methylaniline (515 mg, 2.53 mmol) was dissolved in pyridine (20 ml). Then Intermediate 33 (547 mg, 2.53 mmol) and DMAP (3.09 mg, 0.025 mmol) were added and the resulting mixture was stirred at r.t. for 2 hrs. The solvents were removed in vacuo and the residue was taken up with EtOAc and H2O. The organic layer was washed with sat. NaHCO3 solution and brine, and then dried over Na2SO4. The solvents were removed in vacuo and the resulting residue was recrystallized with MeOH to afford Intermediate 34 as colorless solid. The solvents were removed in vacuo The organic layer was washed with sat. NaHCO3 solution and brine dried over Na2SO4 The solvents were removed in vacuo the resulting residue was recrystallized with MeOH
Source ID: ord-d92f6207ed644b728c3bb7cb677247eaConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Bromo-5-fluoro-2-methylaniline (515 mg, 2.53 mmol) was dissolved in pyridine (20 ml). Then Intermediate 33 (547 mg, 2.53 mmol) and DMAP (3.09 mg, 0.025 mmol) were added and the resulting mixture was stirred at r.t. for 2 hrs. The solvents were removed in vacuo and the residue was taken up with EtOAc and H2O. The organic layer was washed with sat. NaHCO3 solution and brine, and then dried over Na2SO4. The solvents were removed in vacuo and the resulting residue was recrystallized with MeOH to afford Intermediate 34 as colorless solid. The solvents were removed in vacuo The organic layer was washed with sat. NaHCO3 solution and brine dried over Na2SO4 The solvents were removed in vacuo the resulting residue was recrystallized with MeOH
Source ID: ord-d92f6207ed644b728c3bb7cb677247eaConditions: temp:110.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To iron powder (325 mesh, 2.25 g, 40.3 mmol) in 30 ml water and 80 ml isopropanol was added commercially available 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (3.04 g, 13 mmol) in 45 ml isopropanol and NH4Cl (1.46 g, 27.3 mmol). The resulting mixture was heated at 110° C. for 2 h. After evaporation of most of the isopropanol the aq solution was extracted with ethyl acetate three times. The combined organic layers were washed with water and brine, dried over MgSO4, filtered and evaporated. The crude product was used without further purification in the next step. After evaporation of most of the isopropanol the aq solution was extracted with ethyl acetate three times The combined organic layers were washed with water and brine dried over MgSO4 filtered evaporated The crude product was used without further purification in the next step
Source ID: ord-e6322d2c07c0442eb0a7e6b983a5a71aConditions: temp:110.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To iron powder (325 mesh, 2.25 g, 40.3 mmol) in 30 ml water and 80 ml isopropanol was added commercially available 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (3.04 g, 13 mmol) in 45 ml isopropanol and NH4Cl (1.46 g, 27.3 mmol). The resulting mixture was heated at 110° C. for 2 h. After evaporation of most of the isopropanol the aq solution was extracted with ethyl acetate three times. The combined organic layers were washed with water and brine, dried over MgSO4, filtered and evaporated. The crude product was used without further purification in the next step. After evaporation of most of the isopropanol the aq solution was extracted with ethyl acetate three times The combined organic layers were washed with water and brine dried over MgSO4 filtered evaporated The crude product was used without further purification in the next step
Source ID: ord-e6322d2c07c0442eb0a7e6b983a5a71aConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7f23ef3558634da6a7f5806bc2afd55dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of crude 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (5.96 g) in MeOH (90 mL) was added concentrated hydrochloric acid (11.7 mL) and iron (6.1 g) and the reaction mixture was heated to reflux. After 16 h, the mixture was cooled, diluted with DCM, washed with sodium carbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 3-bromo-5-fluoro-2-methyl-phenylamine (1.46 g). the reaction mixture was heated to reflux the mixture was cooled washed with sodium carbonate solution dried (MgSO4) the solvent removed in vacuo The residue was purified
Source ID: ord-5d46f5552a4a40f1baf94a52cce28024Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of crude 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (5.96 g) in MeOH (90 mL) was added concentrated hydrochloric acid (11.7 mL) and iron (6.1 g) and the reaction mixture was heated to reflux. After 16 h, the mixture was cooled, diluted with DCM, washed with sodium carbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 3-bromo-5-fluoro-2-methyl-phenylamine (1.46 g). the reaction mixture was heated to reflux the mixture was cooled washed with sodium carbonate solution dried (MgSO4) the solvent removed in vacuo The residue was purified
Source ID: ord-6cb6aa5e37de4b8f954d2c5358e05f3eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of crude 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (5.96 g) in MeOH (90 mL) was added concentrated hydrochloric acid (11.7 mL) and iron (6.1 g) and the reaction mixture was heated to reflux. After 16 h, the mixture was cooled, diluted with DCM, washed with sodium carbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 3-bromo-5-fluoro-2-methyl-phenylamine (1.46 g). the reaction mixture was heated to reflux the mixture was cooled washed with sodium carbonate solution dried (MgSO4) the solvent removed in vacuo The residue was purified
Source ID: ord-2c1748a6ca2f4908a0a576ee938cb23dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of crude 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (5.96 g) in MeOH (90 mL) was added concentrated hydrochloric acid (11.7 mL) and iron (6.1 g) and the reaction mixture was heated to reflux. After 16 h, the mixture was cooled, diluted with DCM, washed with sodium carbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 3-bromo-5-fluoro-2-methyl-phenylamine (1.46 g). the reaction mixture was heated to reflux the mixture was cooled washed with sodium carbonate solution dried (MgSO4) the solvent removed in vacuo The residue was purified
Source ID: ord-267823c52a944fcfa0044e31d6be9c02Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of crude 1-bromo-5-fluoro-2-methyl-3-nitro-benzene (5.96 g) in MeOH (90 mL) was added concentrated hydrochloric acid (11.7 mL) and iron (6.1 g) and the reaction mixture was heated to reflux. After 16 h, the mixture was cooled, diluted with DCM, washed with sodium carbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 3-bromo-5-fluoro-2-methyl-phenylamine (1.46 g). the reaction mixture was heated to reflux the mixture was cooled washed with sodium carbonate solution dried (MgSO4) the solvent removed in vacuo The residue was purified
Source ID: ord-fc32c4fad49a4e9c8c7a4af179fd9a6cPubChem References
These sources are listed in the compound's public database record.
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