cycloheptanol

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using cycloheptanol (39 mg, 0.34 mmol) as the coupling partner. Concentration (no chromatography) yielded 53 mg (80%) of the titled compound. ESI-MS m/z 388 (MH+), 386 (M−H−). Concentration (no chromatography)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Into a 250 ml reaction flask equipped with magnetic stirrer, heating mantle, thermometer, nitrogen sparger and reflux condenser are placed 11.4 cycloheptanol; 8.1 grams of the ethyl ester of 4-(methylthio)butyric acid and 0.5 grams of a 25% methanolic solution of sodium methoxide. Into a 250 ml reaction flask equipped with magnetic stirrer heating mantle thermometer, nitrogen sparger and reflux condenser

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Into a 250 ml reaction flask equipped with magnetic stirrer, heating mantle, thermometer, nitrogen sparger and reflux condenser are placed 11.4 cycloheptanol; 8.1 grams of the ethyl ester of 4-(methylthio)butyric acid and 0.5 grams of a 25% methanolic solution of sodium methoxide. Into a 250 ml reaction flask equipped with magnetic stirrer heating mantle thermometer, nitrogen sparger and reflux condenser

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Into a 100 ml reaction flask equipped with stirrer, thermometer, reflux condenser and hot plate are placed 45.6 grams of cycloheptanol; 16 grams of 3-mercaptopropionic acid and 0.5 grams of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 12 hours. At the end of the 12 hour period, the reaction mass is cooled and distilled on a micro distillation apparatus yielding the compound having the structure: ##STR147## as confirmed by GLC, IR, NMR and mass spectral analyses. Into a 100 ml reaction flask equipped with stirrer thermometer, reflux condenser The reaction mass is heated to reflux refluxed for a period of 12 hours At the end of the 12 hour period, the reaction mass is cooled distilled on a micro distillation apparatus yielding the compound

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Into a 100 ml reaction flask equipped with stirrer, thermometer, reflux condenser and hot plate are placed 45.6 grams of cycloheptanol; 16 grams of 3-mercaptopropionic acid and 0.5 grams of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 12 hours. At the end of the 12 hour period, the reaction mass is cooled and distilled on a micro distillation apparatus yielding the compound having the structure: ##STR147## as confirmed by GLC, IR, NMR and mass spectral analyses. Into a 100 ml reaction flask equipped with stirrer thermometer, reflux condenser The reaction mass is heated to reflux refluxed for a period of 12 hours At the end of the 12 hour period, the reaction mass is cooled distilled on a micro distillation apparatus yielding the compound

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Reaction: ##STR128## Into a 50 ml reaction flask equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 11.4 grams cycloheptanol; 22 grams of 2-mercaptopropionic acid and 0.5 grams of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 10 hours. At the end of the 10 hour period, the reaction mass is distilled on a micro distillation apparatus to yield the compound having the structure: ##STR129## Reaction ##STR128## Into a 50 ml reaction flask equipped with stirrer thermometer, reflux condenser heating mantle The reaction mass is heated to reflux refluxed for a period of 10 hours At the end of the 10 hour period, the reaction mass is distilled on a micro distillation apparatus to yield the compound

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Reaction: ##STR128## Into a 50 ml reaction flask equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 11.4 grams cycloheptanol; 22 grams of 2-mercaptopropionic acid and 0.5 grams of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 10 hours. At the end of the 10 hour period, the reaction mass is distilled on a micro distillation apparatus to yield the compound having the structure: ##STR129## Reaction ##STR128## Into a 50 ml reaction flask equipped with stirrer thermometer, reflux condenser heating mantle The reaction mass is heated to reflux refluxed for a period of 10 hours At the end of the 10 hour period, the reaction mass is distilled on a micro distillation apparatus to yield the compound

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Into a 100 ml reaction flask equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 28.5 grams of cycloheptanol; 9.2 grams of mercaptoacetic acid and 0.5 grams of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 10 hours. At the end of the 10 hour period, the reaction mass is washed with one 25 ml volume of water followed by drying over anhydrous sodium sulfate. The reaction mass is then distilled in a micro distillation apparatus yielding the compound having the structure ##STR115## Into a 100 ml reaction flask equipped with stirrer thermometer, reflux condenser heating mantle The reaction mass is heated to reflux refluxed for a period of 10 hours At the end of the 10 hour period, the reaction mass is washed with one 25 ml volume of water by drying over anhydrous sodium sulfate The reaction mass is then distilled in a micro distillation apparatus yielding the compound

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Into a 100 ml reaction flask equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 28.5 grams of cycloheptanol; 9.2 grams of mercaptoacetic acid and 0.5 grams of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 10 hours. At the end of the 10 hour period, the reaction mass is washed with one 25 ml volume of water followed by drying over anhydrous sodium sulfate. The reaction mass is then distilled in a micro distillation apparatus yielding the compound having the structure ##STR115## Into a 100 ml reaction flask equipped with stirrer thermometer, reflux condenser heating mantle The reaction mass is heated to reflux refluxed for a period of 10 hours At the end of the 10 hour period, the reaction mass is washed with one 25 ml volume of water by drying over anhydrous sodium sulfate The reaction mass is then distilled in a micro distillation apparatus yielding the compound