(3-fluorophenyl)thiourea

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound is prepared analogously to Example 2-1 step B using 2-bromo-1-(4-bromophenyl)-ethanone and 3-fluorophenylthiourea: (M+H)+350.9.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3-fluorophenylthiourea (20.0 g, 166.7 mmol) and methyl iodide (24.8 g, 175.0 mmol) in 300 ml of ethanol is stirred at RT for 2 days. It is then heated to reflux for 30 min., cooled and stripped of solvent to give S-methyl-3-fluorophenylisothiourea hydroiodide, an orange solid. It is then heated to reflux for 30 min. cooled

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound is prepared analogously to Example 2-1 step B using 2-bromo-1-(4-bromophenyl)-ethanone and 3-fluorophenylthiourea: (M+H)+ 350.9.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3-fluorophenylthiourea (20.0 g, 166.7 mmol) and methyl iodide (24.8 g, 175.0 mmol) in 300 ml of ethanol is stirred at RT for 2 days. It is then heated to reflux for 30 min., cooled and stripped of solvent to give S-methyl-3-fluorophenylisothiourea hydroiodide, an orange solid. It is then heated to reflux for 30 min. cooled