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CC(C)N1CCN(CC1)CCCNChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 3-(4-propan-2-ylpiperazin-1-yl)propan-1-amine |
|---|---|
| IUPAC Name | — |
| CAS Number | 4553-26-8 |
| Database ID | 12802956 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
3-(4-propan-2-ylpiperazin-1-yl)propan-1-amine (CAS 4553-26-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 12802956
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c2d90b7880414f1180af8e6083d25d8dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of potassium hydroxide (4.9 g) in methanol (40 ml) was added 3-(4-isopropyl-1-piperazinyl)propylamine (14.7 g) and thereto was added carbon disulfide (6.0 g) under ice cooling over a period of 20 minutes. The resulting mixture was stirred for 3.5 hours under ice cooling. The reaction mixture was evaporated under reduced pressure. The residual oil was dissolved in water (40 ml) and washed with diethyl ether. The washed aqueous layer was ice-cooled and thereto was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes. The resulting mixture was stirred for 2 hours under ice-cooling extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and then evaporated to give an oil of methyl N-[3-(4-isopropyl-1-piperazinyl)propyl]dithiocarbamate (15.6 g). The reaction mixture was evaporated under reduced pressure The residual oil was dissolved in water (40 ml) washed with diethyl ether cooled was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes The resulting mixture was stirred for 2 hours under ice- cooling extracted with chloroform The extract was washed with water dried over magnesium sulfate evaporated
Source ID: ord-d728dec553b2404cbd7da5dceadcdd54Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of N-[3-(4-isopropyl-1-piperazinyl)propyl]phthalimide (43.1 g) in ethanol (350 ml) was added 100% hydrazine hydrate (11.2 g). The resulting mixture was refluxed with stirring for 3 hours. The reaction mixture was cooled and then filtered. The filter cake was washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residual oil was subjected to column chromatography (aluminum oxide), eluting with a mixture of chloroform and methanol (20:1). The fractions containing the object compound were collected and then evaporated under reduced pressure. The residual oil was distilled under reduced pressure to give 3-(4-isopropyl-1-piperazinyl)propylamine (15.0 g), (bp 45 mmHg/150° C.). The resulting mixture was refluxed The reaction mixture was cooled filtered The filter cake was washed with ethanol The filtrate and washing concentrated under reduced pressure eluting with a mixture of chloroform and methanol (20:1) The fractions containing the object compound were collected evaporated under reduced pressure The residual oil was distilled under reduced pressure
Source ID: ord-2aab1a12999f4586891413b36e07e426Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of potassium hydroxide (4.9 g) in methanol (40 ml) was added 3-(4-isopropyl-1-piperazinyl)propylamine (14.7 g) and thereto was added carbon disulfide (6.0 g) under ice cooling over a period of 20 minutes. The resulting mixture was stirred for 3.5 hours under ice cooling. The reaction mixture was evaporated under reduced pressure. The residual oil was dissolved in water (40 ml) and washed with diethyl ether. The washed aqueous layer was ice-cooled and thereto was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes. The resulting mixture was stirred for 2 hours under ice-cooling extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and then evaporated to give an oil of methyl N-[3-(4-isopropyl-1-piperazinyl)propyl]dithiocarbamate (15.6 g). The reaction mixture was evaporated under reduced pressure The residual oil was dissolved in water (40 ml) washed with diethyl ether cooled was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes The resulting mixture was stirred for 2 hours under ice- cooling extracted with chloroform The extract was washed with water dried over magnesium sulfate evaporated
Source ID: ord-d728dec553b2404cbd7da5dceadcdd54Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of potassium hydroxide (4.9 g) in methanol (40 ml) was added 3-(4-isopropyl-1-piperazinyl)propylamine (14.7 g) and thereto was added carbon disulfide (6.0 g) under ice cooling over a period of 20 minutes. The resulting mixture was stirred for 3.5 hours under ice cooling. The reaction mixture was evaporated under reduced pressure. The residual oil was dissolved in water (40 ml) and washed with diethyl ether. The washed aqueous layer was ice-cooled and thereto was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes. The resulting mixture was stirred for 2 hours under ice-cooling extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and then evaporated to give an oil of methyl N-[3-(4-isopropyl-1-piperazinyl)propyl]dithiocarbamate (15.6 g). The reaction mixture was evaporated under reduced pressure The residual oil was dissolved in water (40 ml) washed with diethyl ether cooled was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes The resulting mixture was stirred for 2 hours under ice- cooling extracted with chloroform The extract was washed with water dried over magnesium sulfate evaporated
Source ID: ord-d728dec553b2404cbd7da5dceadcdd54Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of N-[3-(4-isopropyl-1-piperazinyl)propyl]phthalimide (43.1 g) in ethanol (350 ml) was added 100% hydrazine hydrate (11.2 g). The resulting mixture was refluxed with stirring for 3 hours. The reaction mixture was cooled and then filtered. The filter cake was washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residual oil was subjected to column chromatography (aluminum oxide), eluting with a mixture of chloroform and methanol (20:1). The fractions containing the object compound were collected and then evaporated under reduced pressure. The residual oil was distilled under reduced pressure to give 3-(4-isopropyl-1-piperazinyl)propylamine (15.0 g), (bp 45 mmHg/150° C.). The resulting mixture was refluxed The reaction mixture was cooled filtered The filter cake was washed with ethanol The filtrate and washing concentrated under reduced pressure eluting with a mixture of chloroform and methanol (20:1) The fractions containing the object compound were collected evaporated under reduced pressure The residual oil was distilled under reduced pressure
Source ID: ord-2aab1a12999f4586891413b36e07e426Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of N-[3-(4-isopropyl-1-piperazinyl)propyl]phthalimide (43.1 g) in ethanol (350 ml) was added 100% hydrazine hydrate (11.2 g). The resulting mixture was refluxed with stirring for 3 hours. The reaction mixture was cooled and then filtered. The filter cake was washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residual oil was subjected to column chromatography (aluminum oxide), eluting with a mixture of chloroform and methanol (20:1). The fractions containing the object compound were collected and then evaporated under reduced pressure. The residual oil was distilled under reduced pressure to give 3-(4-isopropyl-1-piperazinyl)propylamine (15.0 g), (bp 45 mmHg/150° C.). The resulting mixture was refluxed The reaction mixture was cooled filtered The filter cake was washed with ethanol The filtrate and washing concentrated under reduced pressure eluting with a mixture of chloroform and methanol (20:1) The fractions containing the object compound were collected evaporated under reduced pressure The residual oil was distilled under reduced pressure
Source ID: ord-2aab1a12999f4586891413b36e07e426Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c2d90b7880414f1180af8e6083d25d8dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Using the method of 3-(4-isopropylpiperazin-1-yl)-propylamine, the title compound is synthesized from racemic 3-isopropyl-piperazine-1-carboxylic acid tert-butyl ester and isolated as a tan oil. isolated as a tan oil
Source ID: ord-e4bd8d2117cf4ed4a6762ed5529b98b2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Hydrazine (8.63 g, 270 mmol) is added to a stirred suspension of 2-[3-(4-isopropylpiperazin-1-yl)-propyl]-isoindole-1,3-dione (17.0 g, 53.9 mmol) in anhydrous ethanol (400 mL). The resultant mixture is heated in an oil bath at 75° C. for 16 hours. At ambient temperature, dichloromethane (300 mL) is added to the mixture and the suspension is allowed to stir for 10 minutes. After filtration and concentration, the title compound is obtained as a tan oil (8.12 g, 81% yield). After filtration and concentration
Source ID: ord-be701dd17359432ea03ad3c4cbef9645Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of potassium hydroxide (4.9 g) in methanol (40 ml) was added 3-(4-isopropyl-1-piperazinyl)propylamine (14.7 g) and thereto was added carbon disulfide (6.0 g) under ice cooling over a period of 20 minutes. The resulting mixture was stirred for 3.5 hours under ice cooling. The reaction mixture was evaporated under reduced pressure. The residual oil was dissolved in water (40 ml) and washed with diethyl ether. The washed aqueous layer was ice-cooled and thereto was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes. The resulting mixture was stirred for 2 hours under ice-cooling extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and then evaporated to give an oil of methyl N-[3-(4-isopropyl-1-piperazinyl)propyl]dithiocarbamate (15.6 g). The reaction mixture was evaporated under reduced pressure The residual oil was dissolved in water (40 ml) washed with diethyl ether cooled was added methyl iodide (11.3 g) with stirring over a period of about 5 minutes The resulting mixture was stirred for 2 hours under ice- cooling extracted with chloroform The extract was washed with water dried over magnesium sulfate evaporated
Source ID: ord-ee313229b9e143e381a7ccb5a9d71667Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of N-[3-(4-isopropyl-1-piperazinyl)propyl]phthalimide (43.1 g) in ethanol (350 ml) was added 100% hydrazine hydrate (11.2 g). The resulting mixture was refluxed with stirring for 3 hours. The reaction mixture was cooled and then filtered. The filter cake was washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residual oil was subjected to column chromatography (aluminum oxide), eluting with a mixture of chloroform and methanol (20:1). The fractions containing the object compound were collected and then evaporated under reduced pressure. The residual oil was distilled under reduced pressure to give 3-(4-isopropyl-1-piperazinyl)propylamine (15.0 g), (bp 45 mmHg/150° C.). The resulting mixture was refluxed The reaction mixture was cooled filtered The filter cake was washed with ethanol The filtrate and washing concentrated under reduced pressure eluting with a mixture of chloroform and methanol (20:1) The fractions containing the object compound were collected evaporated under reduced pressure The residual oil was distilled under reduced pressure
Source ID: ord-de84a78453be4cba959090a31cb1c7f4PubChem References
These sources are listed in the compound's public database record.
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