cyclohexylboronic acid

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a failed attempt to couple cyclohexyl boronic acid with tert-butyl N-{[1-(2-bromobenzyl)-4-hydroxy-2-oxo-6-(1,3-thiazol-4-ylcarbonyl)-2,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridin-3-yl]carbonyl}glycinate (prepared in similar fashion to Intermediate 5), and using a similar procedure to that described in Example 49 Step A, the above side product, compound E54-1 obtained. HPLC/MS: 454.9 (M+1); Rt=2.67 min. the above side product, compound E54-1 obtained

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a failed attempt to couple cyclohexyl boronic acid with tert-butyl N-{[1-(2-bromobenzyl)-4-hydroxy-2-oxo-6-(1,3-thiazol-4-ylcarbonyl)-2,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridin-3-yl]carbonyl}glycinate (prepared in similar fashion to Intermediate 5), and using a similar procedure to that described in Example 49 Step A, the above side product, compound E54-1 obtained. HPLC/MS: 454.9 (M+1); Rt=2.67 min. the above side product, compound E54-1 obtained

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a failed attempt to couple cyclohexyl boronic acid with tert-butyl N-{[1-(2-bromobenzyl)-4-hydroxy-2-oxo-6-(1,3-thiazol-4-ylcarbonyl)-2,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridin-3-yl]carbonyl}glycinate (prepared in similar fashion to Intermediate 5), and using a similar procedure to that described in Example 49 Step A, the above side product, compound E54-1 obtained. HPLC/MS: 454.9 (M+1); Rt=2.67 min. the above side product, compound E54-1 obtained