N-(piperidin-1-ylmethyl)benzamide

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Benzamide (0.5 g, 0.4 mmol) was dissolved in 5 mL of methanol. To this stirred solution piperidine (0.35 mL, 0.4 mol) was added and the resulting solution was cooled in an ice bath. Formaldehyde (0.31 mL, 0.4 mol, 37% in water) was added dropwise. The solution was stirred for 10 min and then it was refluxed for 4 h. After cooling, the solvents were evaporated to give Mannich base 15 as a white solid 0.78 g (87% yield). the resulting solution was cooled in an ice bath it was refluxed for 4 h After cooling the solvents were evaporated