(2,5-dioxopyrrolidin-1-yl) 3,3,3-trifluoropropanoate

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The compound (66 mg, 0.15 mmol) prepared in Example 117 was dissolved in dichloromethane (10 ml). Diisopropylethylamine (0.08 ml, 0.44 mmol) and 3,3,3-trifluoropropionic acid 2,5-dioxo-pyrrolidin-1-yl ester (29 mg, 0.13 mmol) were added thereto, and the mixture was stirred for 8 h at room temperature. After completion of the reaction, water was added. The mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and filtered. The filtrate was distilled under reduced pressure, and purified by column chromatography to give the title compound (6 mg, Yield 9%). was added The mixture was extracted with ethyl acetate dried over anhydrous magnesium sulfate filtered The filtrate was distilled under reduced pressure purified by column chromatography