1-(4-fluorophenyl)-N-methylmethanamine

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 17.1 g (0.14 mol) of N-acetyl-4-piperidone and 16.9 g (0.14 mol) of N-(4-fluorobenzyl)-N-methylamine were reacted in a similar manner to Preparation 6. 25.1 g of 1-acetyl-4-(N-(4-fluorobenzyl)-N-methylamino)piperidine were obtained.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 17.1 g (0.14 mol) of N-acetyl-4-piperidone and 16.9 g (0.14 mol) of N-(4-fluorobenzyl)-N-methylamine were reacted in a similar manner to Preparation 6. 25.1 g of 1-acetyl-4-(N-(4-fluorobenzyl)-N-methylamino)piperidine were obtained.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: This compound was prepared from 4-Fluoro-N-methylbenzylamine which in turn was prepared from 4-Fluoro-N-methylbenzamide. Practical details are as follows: 4-Fluorobenzoyl chloride (25g) was added dropwise to a stirred aqueous solution of methylamine (40% w/v; 250 ml) at 0° C. over 30 min. The mixture was stirred for 12 h at room temperature, concentrated to half volume and the resulting crystalline precipitate was collected and recrystallized from water to furnish the N-methylbenzamide as colourless needles, (24.1 g; 89.1%), m.p. 131°-132° C. concentrated to half volume the resulting crystalline precipitate was collected recrystallized from water

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: This compound was prepared from 4-Fluoro-N-methylbenzylamine which in turn was prepared from 4-Fluoro-N-methylbenzamide. Practical details are as follows: 4-Fluorobenzoyl chloride (25g) was added dropwise to a stirred aqueous solution of methylamine (40% w/v; 250 ml) at 0° C. over 30 min. The mixture was stirred for 12 h at room temperature, concentrated to half volume and the resulting crystalline precipitate was collected and recrystallized from water to furnish the N-methylbenzamide as colourless needles, (24.1 g; 89.1%), m.p. 131°-132° C. concentrated to half volume the resulting crystalline precipitate was collected recrystallized from water