2-hydroxy-N-propan-2-ylacetamide

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The procedure is as in Example 22, but starting with N-isopropylglycolamide (5.3 g) in tetrahydrofuran (250 cc), an oily suspension (50% by weight; 2.2 g) of sodium hydride and 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (10 g). After purification by recrystallization in acetonitrile, [2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyloxy]-N-isopropylacetamide (4 g), m.p. 188° C., is obtained. After purification by recrystallization in acetonitrile